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ADAMTSL5 ADAMTS like 5 [ Homo sapiens (human) ]

Gene ID: 339366, updated on 4-Jan-2025

Summary

Official Symbol
ADAMTSL5provided by HGNC
Official Full Name
ADAMTS like 5provided by HGNC
Primary source
HGNC:HGNC:27912
See related
Ensembl:ENSG00000185761 AllianceGenome:HGNC:27912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
THSD6
Summary
Enables heparin binding activity and microfibril binding activity. Predicted to be involved in extracellular matrix organization. Located in extracellular region and microfibril. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in endometrium (RPKM 3.3), heart (RPKM 2.8) and 21 other tissues See more
Orthologs
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Genomic context

See ADAMTSL5 in Genome Data Viewer
Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1505022..1513019, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1475471..1483468, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1505021..1513018, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1482223-1482834 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9724 Neighboring gene receptor accessory protein 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1497018-1497572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1507743-1508592 Neighboring gene uncharacterized LOC124904609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9727 Neighboring gene uncharacterized LOC107985337 Neighboring gene polo like kinase 5 (inactive)

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding PubMed 
enables microfibril binding PubMed 
enables protein binding PubMed 
Component Evidence Code Pubs
located_in extracellular matrix PubMed 
located_in extracellular region PubMed 
located_in microfibril PubMed 

General protein information

Preferred Names
ADAMTS-like protein 5
Names
ADAMTSL-5
thrombospondin type-1 domain-containing protein 6
thrombospondin, type I, domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367197.1NP_001354126.1  ADAMTS-like protein 5 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC027307, AW167554, BX951496
    UniProtKB/Swiss-Prot
    B4DXK7, Q6ZMM2, Q8IW95
    Conserved Domains (4) summary
    smart00209
    Location:4897
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:375476
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206311
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:106174
    ADAM_CR; ADAM cysteine-rich
  2. NM_213604.3NP_998769.2  ADAMTS-like protein 5 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK131571, BC040620, BC119796, DR979736
    Consensus CDS
    CCDS12071.1
    UniProtKB/TrEMBL
    X6R4H8
    Related
    ENSP00000327608.3, ENST00000330475.9
    Conserved Domains (4) summary
    smart00209
    Location:3887
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:365466
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:196301
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:96164
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1505022..1513019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438758.1XP_047294714.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  2. XM_047438757.1XP_047294713.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  3. XM_047438756.1XP_047294712.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  4. XM_047438755.1XP_047294711.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  5. XM_011527961.2XP_011526263.1  ADAMTS-like protein 5 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:4897
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:379480
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:206315
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:106174
    ADAM_CR; ADAM cysteine-rich
  6. XM_017026745.2XP_016882234.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    X6R4H8
    Conserved Domains (4) summary
    smart00209
    Location:3887
    TSP1; Thrombospondin type 1 repeats
    cd03523
    Location:365466
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    pfam05986
    Location:196301
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:96164
    ADAM_CR; ADAM cysteine-rich
  7. XM_047438751.1XP_047294707.1  ADAMTS-like protein 5 isoform X2

  8. XM_047438754.1XP_047294710.1  ADAMTS-like protein 5 isoform X4

  9. XM_047438752.1XP_047294708.1  ADAMTS-like protein 5 isoform X4

  10. XM_047438753.1XP_047294709.1  ADAMTS-like protein 5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1475471..1483468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320836.1XP_054176811.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  2. XM_054320835.1XP_054176810.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  3. XM_054320834.1XP_054176809.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  4. XM_054320833.1XP_054176808.1  ADAMTS-like protein 5 isoform X5

    UniProtKB/TrEMBL
    A4QPG6
  5. XM_054320827.1XP_054176802.1  ADAMTS-like protein 5 isoform X1

  6. XM_054320829.1XP_054176804.1  ADAMTS-like protein 5 isoform X3

    UniProtKB/TrEMBL
    X6R4H8
  7. XM_054320828.1XP_054176803.1  ADAMTS-like protein 5 isoform X2

  8. XM_054320832.1XP_054176807.1  ADAMTS-like protein 5 isoform X4

  9. XM_054320830.1XP_054176805.1  ADAMTS-like protein 5 isoform X4

  10. XM_054320831.1XP_054176806.1  ADAMTS-like protein 5 isoform X4

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