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ACSL3 acyl-CoA synthetase long chain family member 3 [ Homo sapiens (human) ]

Gene ID: 2181, updated on 5-Jan-2025

Summary

Official Symbol
ACSL3provided by HGNC
Official Full Name
acyl-CoA synthetase long chain family member 3provided by HGNC
Primary source
HGNC:HGNC:3570
See related
Ensembl:ENSG00000123983 MIM:602371; AllianceGenome:HGNC:3570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS3; FACL3; LACS3; LACS 3; PRO2194
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 44.8), brain (RPKM 31.0) and 24 other tissues See more
Orthologs
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Genomic context

See ACSL3 in Genome Data Viewer
Location:
2q36.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (222861036..222944639)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (223346613..223427414)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223725754..223809357)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17169 Neighboring gene Sharpr-MPRA regulatory region 7025 Neighboring gene uncharacterized LOC105373903 Neighboring gene ribosomal protein L31 pseudogene 17 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:223659282-223660204 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:223660205-223661127 Neighboring gene Sharpr-MPRA regulatory region 2575 Neighboring gene Sharpr-MPRA regulatory region 9896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12374 Neighboring gene NANOG hESC enhancer GRCh37_chr2:223730990-223731491 Neighboring gene MPRA-validated peak4046 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:223770847-223771419 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:223771420-223771991 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:223772163-223772785 Neighboring gene autophagy related 12 pseudogene 2 Neighboring gene ACSL3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12375 Neighboring gene zinc finger protein 79 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17170 Neighboring gene Sharpr-MPRA regulatory region 15139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:223917216-223917763 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with acyl-CoA synthetase long-chain family member 3 (ACSL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
enables arachidonate-CoA ligase activity  
enables long-chain fatty acid-CoA ligase activity  
enables long-chain fatty acid-CoA ligase activity PubMed 
enables long-chain fatty acid-CoA ligase activity  
enables long-chain fatty acid-CoA ligase activity  
enables medium-chain fatty acid-CoA ligase activity  
enables palmitoyl-CoA ligase activity  
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein kinase binding PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum membrane  
is_active_in lipid droplet  
located_in lipid droplet PubMed 
located_in membrane PubMed 
located_in mitochondrial outer membrane  
located_in perinuclear region of cytoplasm PubMed 
located_in peroxisomal membrane  
is_active_in plasma membrane  

General protein information

Preferred Names
fatty acid CoA ligase Acsl3
Names
arachidonate--CoA ligase
fatty-acid-Coenzyme A ligase, long-chain 3
lignoceroyl-CoA synthase
long-chain acyl-CoA synthetase 3
long-chain-fatty-acid--CoA ligase 3
medium-chain acyl-CoA ligase Acsl3
NP_001341087.1
NP_001341088.1
NP_004448.2
NP_976251.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354158.2NP_001341087.1  fatty acid CoA ligase Acsl3

    Status: REVIEWED

    Source sequence(s)
    AC013476, AC016712
    Consensus CDS
    CCDS2455.1
    UniProtKB/Swiss-Prot
    O95573, Q60I92, Q8IUM9
    UniProtKB/TrEMBL
    B2RBE0
    Related
    ENSP00000505793.1, ENST00000680395.1
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. NM_001354159.2NP_001341088.1  fatty acid CoA ligase Acsl3

    Status: REVIEWED

    Source sequence(s)
    AC013476, AC016712
    Consensus CDS
    CCDS2455.1
    UniProtKB/Swiss-Prot
    O95573, Q60I92, Q8IUM9
    UniProtKB/TrEMBL
    B2RBE0
    Related
    ENSP00000505400.1, ENST00000680251.1
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. NM_004457.5NP_004448.2  fatty acid CoA ligase Acsl3

    See identical proteins and their annotated locations for NP_004448.2

    Status: REVIEWED

    Source sequence(s)
    AC013476, BC041692
    Consensus CDS
    CCDS2455.1
    UniProtKB/Swiss-Prot
    O95573, Q60I92, Q8IUM9
    UniProtKB/TrEMBL
    B2RBE0
    Related
    ENSP00000350012.3, ENST00000357430.8
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. NM_203372.3NP_976251.1  fatty acid CoA ligase Acsl3

    See identical proteins and their annotated locations for NP_976251.1

    Status: REVIEWED

    Source sequence(s)
    AC013476, AC016712
    Consensus CDS
    CCDS2455.1
    UniProtKB/Swiss-Prot
    O95573, Q60I92, Q8IUM9
    UniProtKB/TrEMBL
    B2RBE0
    Related
    ENSP00000375918.3, ENST00000392066.7
    Conserved Domains (1) summary
    cl17068
    Location:30717
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    222861036..222944639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    223346613..223427414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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