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Chmp2b charged multivesicular body protein 2B [ Mus musculus (house mouse) ]

Gene ID: 68942, updated on 4-Jan-2025

Summary

Official Symbol
Chmp2bprovided by MGI
Official Full Name
charged multivesicular body protein 2Bprovided by MGI
Primary source
MGI:MGI:1916192
See related
Ensembl:ENSMUSG00000004843 AllianceGenome:MGI:1916192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190006E07Rik
Summary
Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including regulation of cell cycle process; regulation of synapse organization; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in glutamatergic synapse; multivesicular body; and postsynaptic density. Predicted to colocalize with late endosome and lysosome. Is expressed in several structures, including central nervous system; fronto-nasal process; genitourinary system; spleen; and vibrissa. Used to study frontotemporal dementia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; frontotemporal dementia; and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 28.8), duodenum adult (RPKM 25.1) and 28 other tissues See more
Orthologs
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Genomic context

See Chmp2b in Genome Data Viewer
Location:
16 C1.3; 16 37.26 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (65336014..65359648, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (65539128..65562762, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene geminin pseudogene Neighboring gene STARR-seq mESC enhancer starr_41163 Neighboring gene STARR-seq mESC enhancer starr_41164 Neighboring gene STARR-seq mESC enhancer starr_41165 Neighboring gene STARR-seq mESC enhancer starr_41166 Neighboring gene STARR-seq mESC enhancer starr_41167 Neighboring gene STARR-positive B cell enhancer ABC_E7472 Neighboring gene STARR-seq mESC enhancer starr_41168 Neighboring gene POU domain, class 1, transcription factor 1 Neighboring gene predicted gene, 36457 Neighboring gene STARR-positive B cell enhancer mm9_chr16:65629532-65629832 Neighboring gene STARR-seq mESC enhancer starr_41170 Neighboring gene STARR-seq mESC enhancer starr_41171 Neighboring gene predicted gene, 57637

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in autophagosome maturation  
involved_in autophagy  
involved_in cognition  
involved_in cognition  
involved_in endosome organization  
involved_in endosome transport via multivesicular body sorting pathway  
involved_in late endosome to lysosome transport  
involved_in late endosome to vacuole transport  
involved_in membrane fission PubMed 
involved_in midbody abscission  
involved_in mitotic metaphase chromosome alignment  
involved_in modulation of chemical synaptic transmission  
involved_in modulation of chemical synaptic transmission  
involved_in multivesicular body assembly PubMed 
involved_in multivesicular body sorting pathway  
involved_in multivesicular body-lysosome fusion PubMed 
involved_in neuron cellular homeostasis  
involved_in neuron cellular homeostasis  
involved_in nuclear membrane reassembly  
involved_in nucleus organization  
involved_in plasma membrane repair  
involved_in protein transport  
involved_in protein transport  
involved_in regulation of centrosome duplication  
involved_in regulation of centrosome duplication  
involved_in regulation of mitotic spindle assembly  
involved_in regulation of modification of postsynaptic structure  
involved_in regulation of modification of postsynaptic structure  
involved_in regulation of postsynapse organization  
involved_in regulation of postsynapse organization  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
involved_in vesicle fusion with vacuole PubMed 
involved_in viral budding from plasma membrane  
involved_in viral budding via host ESCRT complex  
involved_in viral release from host cell  
Items 1 - 25 of 35
Items 1 - 20 of 24
Component Evidence Code Pubs
part_of ESCRT III complex  
part_of ESCRT III complex  
part_of ESCRT III complex  
located_in amphisome membrane  
located_in autophagosome membrane  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
colocalizes_with endosome  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in kinetochore  
located_in kinetochore microtubule  
colocalizes_with late endosome  
located_in lysosomal membrane  
colocalizes_with lysosome  
located_in midbody  
is_active_in multivesicular body  
located_in multivesicular body membrane  
part_of nuclear pore  
colocalizes_with plasma membrane  
located_in plasma membrane  
located_in postsynaptic density  
is_active_in postsynaptic density  
Items 1 - 20 of 24

General protein information

Preferred Names
charged multivesicular body protein 2b
Names
chromatin modifying protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026879.3NP_081155.1  charged multivesicular body protein 2b

    See identical proteins and their annotated locations for NP_081155.1

    Status: VALIDATED

    Source sequence(s)
    AK084111, BC055809, CT009578
    Consensus CDS
    CCDS28269.1
    UniProtKB/Swiss-Prot
    Q80UZ4, Q8BJF9, Q9CT65
    Related
    ENSMUSP00000004965.7, ENSMUST00000004965.8
    Conserved Domains (1) summary
    pfam03357
    Location:16185
    Snf7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    65336014..65359648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160106.1XP_036015999.1  charged multivesicular body protein 2b isoform X1

    UniProtKB/TrEMBL
    A0A338P7L8
    Related
    ENSMUSP00000156381.2, ENSMUST00000231259.2
    Conserved Domains (1) summary
    pfam03357
    Location:12181
    Snf7
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