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Sart1 spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP [ Rattus norvegicus (Norway rat) ]

Gene ID: 29678, updated on 4-Jan-2025

Summary

Official Symbol
Sart1provided by RGD
Official Full Name
spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNPprovided by RGD
Primary source
RGD:61930
See related
EnsemblRapid:ENSRNOG00000020475 AllianceGenome:RGD:61930
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in mRNA cis splicing, via spliceosome; maturation of 5S rRNA; and positive regulation of cytotoxic T cell differentiation. Predicted to be located in Cajal body; Golgi apparatus; and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; and catalytic step 2 spliceosome. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 107.2), Lung (RPKM 90.7) and 9 other tissues See more
Orthologs
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Genomic context

See Sart1 in Genome Data Viewer
Location:
1q43
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212119824..212128517, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202690472..202699136, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220762496..220771158, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene barrier to autointegration nuclear assembly factor 1 Neighboring gene eukaryotic translation initiation factor 1A domain containing Neighboring gene uncharacterized LOC134483957 Neighboring gene testis specific 10 interacting protein Neighboring gene Dr1 associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mRNA cis splicing, via spliceosome  
involved_in mRNA splicing, via spliceosome  
involved_in mRNA splicing, via spliceosome  
involved_in maturation of 5S rRNA  
involved_in positive regulation of cytotoxic T cell differentiation  
Component Evidence Code Pubs
located_in Cajal body  
located_in Golgi apparatus  
located_in Golgi apparatus  
part_of U2-type precatalytic spliceosome  
part_of U4/U6 x U5 tri-snRNP complex  
part_of U4/U6 x U5 tri-snRNP complex  
part_of U4/U6 x U5 tri-snRNP complex  
part_of catalytic step 2 spliceosome  
located_in nuclear speck  
located_in nuclear speck  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
U4/U6.U5 tri-snRNP-associated protein 1
Names
SART-1
SART1, U4/U6.U5 tri-snRNP-associated protein 1
rSART-1
squamous cell carcinoma antigen recognized by T cells 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031596.1NP_113784.1  U4/U6.U5 tri-snRNP-associated protein 1

    See identical proteins and their annotated locations for NP_113784.1

    Status: PROVISIONAL

    Source sequence(s)
    AB014722
    UniProtKB/Swiss-Prot
    Q5XIW8, Q9Z314
    UniProtKB/TrEMBL
    A6HZ46
    Related
    ENSRNOP00000027812.2, ENSRNOT00000027811.5
    Conserved Domains (1) summary
    pfam03343
    Location:118759
    SART-1; SART-1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212119824..212128517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010066402.1 RNA Sequence

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