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Trmt112 tRNA methyltransferase 11-2 [ Mus musculus (house mouse) ]

Gene ID: 67674, updated on 4-Jan-2025

Summary

Official Symbol
Trmt112provided by MGI
Official Full Name
tRNA methyltransferase 11-2provided by MGI
Primary source
MGI:MGI:1914924
See related
Ensembl:ENSMUSG00000038812 AllianceGenome:MGI:1914924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trm112p; 0610038D11Rik
Summary
Predicted to enable protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in peptidyl-glutamine methylation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; gut; limb bud; lung; and sensory organ. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 69.5), adrenal adult (RPKM 52.7) and 28 other tissues See more
Orthologs
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Genomic context

See Trmt112 in Genome Data Viewer
Location:
19 A; 19 5.08 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6887066..6888396)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6909698..6911028)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 88B Neighboring gene predicted gene, 54051 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6946569-6946770 Neighboring gene peroxiredoxin 5 Neighboring gene estrogen related receptor, alpha Neighboring gene microRNA 6990 Neighboring gene STARR-positive B cell enhancer ABC_E780 Neighboring gene cation channel sperm associated auxiliary subunit zeta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding PubMed 
enables protein heterodimerization activity  
enables protein heterodimerization activity  
enables protein methyltransferase activity PubMed 
enables tRNA methyltransferase activator activity  
enables tRNA methyltransferase activator activity  
enables tRNA methyltransferase activator activity  
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA  
involved_in maturation of SSU-rRNA  
involved_in peptidyl-glutamine methylation PubMed 
involved_in peptidyl-glutamine methylation  
involved_in positive regulation of rRNA processing  
involved_in positive regulation of rRNA processing  
involved_in positive regulation of rRNA processing  
involved_in rRNA (guanine-N7)-methylation  
involved_in rRNA (guanine-N7)-methylation  
involved_in rRNA methylation  
involved_in rRNA methylation  
involved_in tRNA methylation  
involved_in tRNA methylation  
involved_in transcription initiation-coupled chromatin remodeling  
involved_in transcription initiation-coupled chromatin remodeling  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
part_of protein-containing complex PubMed 
part_of tRNA (m2G10) methyltransferase complex  

General protein information

Preferred Names
multifunctional methyltransferase subunit TRM112-like protein
Names
TRM112-like protein
tRNA methyltransferase 11-2 homolog
tRNA methyltransferase 112 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166370.1NP_001159842.1  multifunctional methyltransferase subunit TRM112-like protein

    See identical proteins and their annotated locations for NP_001159842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer and more frequently occurring transcript. Both variants encode the same protein.
    Source sequence(s)
    BC087959, BE951374, DV654053
    Consensus CDS
    CCDS29508.1
    UniProtKB/Swiss-Prot
    Q91YP8, Q9D1N6, Q9DCG9
    UniProtKB/TrEMBL
    Q5M8M3
    Related
    ENSMUSP00000112250.4, ENSMUST00000116551.10
    Conserved Domains (1) summary
    pfam03966
    Location:86112
    Trm112p; Trm112p-like protein
  2. NM_026306.3NP_080582.3  multifunctional methyltransferase subunit TRM112-like protein

    See identical proteins and their annotated locations for NP_080582.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    BC087959, BE951374
    Consensus CDS
    CCDS29508.1
    UniProtKB/Swiss-Prot
    Q91YP8, Q9D1N6, Q9DCG9
    UniProtKB/TrEMBL
    Q5M8M3
    Related
    ENSMUSP00000085591.8, ENSMUST00000088257.14
    Conserved Domains (1) summary
    pfam03966
    Location:86112
    Trm112p; Trm112p-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6887066..6888396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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