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Ntn1 netrin 1 [ Mus musculus (house mouse) ]

Gene ID: 18208, updated on 17-Dec-2024

Summary

Official Symbol
Ntn1provided by MGI
Official Full Name
netrin 1provided by MGI
Primary source
MGI:MGI:105088
See related
Ensembl:ENSMUSG00000020902 AllianceGenome:MGI:105088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Netrin-1
Summary
Predicted to be an extracellular matrix structural constituent. Involved in chemorepulsion of axon and regulation of synapse assembly. Acts upstream of or within several processes, including generation of neurons; inner ear morphogenesis; and regulation of neurogenesis. Located in basement membrane and cytoplasm. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lung; and sensory organ. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in lung adult (RPKM 25.3), colon adult (RPKM 12.9) and 23 other tissues See more
Orthologs
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Genomic context

See Ntn1 in Genome Data Viewer
Location:
11 B3; 11 41.45 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68100190..68277652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68209364..68386826, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene syntaxin 8 Neighboring gene STARR-seq mESC enhancer starr_29808 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:67939507-67939823 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68012718-68012928 Neighboring gene expressed sequence C78197 Neighboring gene microRNA 6406 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084195-68084304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084658-68084931 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084370-68084566 Neighboring gene STARR-seq mESC enhancer starr_29815 Neighboring gene STARR-seq mESC enhancer starr_29816 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68245166-68245319 Neighboring gene STARR-positive B cell enhancer mm9_chr11:68245418-68245719 Neighboring gene predicted gene, 31954 Neighboring gene predicted gene, 32046

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent PubMed 
enables protein binding PubMed 
Items 1 - 25 of 36
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction  
involved_in Cdc42 protein signal transduction  
involved_in Ras protein signal transduction  
involved_in Ras protein signal transduction  
involved_in animal organ morphogenesis  
acts_upstream_of_or_within anterior/posterior axon guidance PubMed 
involved_in apoptotic process  
acts_upstream_of_or_within axon guidance PubMed 
acts_upstream_of_or_within axon guidance PubMed 
acts_upstream_of_or_within axonogenesis PubMed 
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of_or_within cell-cell adhesion PubMed 
involved_in chemorepulsion of axon PubMed 
involved_in dendrite development  
acts_upstream_of glial cell proliferation PubMed 
acts_upstream_of_or_within inner ear morphogenesis PubMed 
acts_upstream_of_or_within mammary gland development PubMed 
acts_upstream_of_or_within mammary gland duct morphogenesis PubMed 
involved_in motor neuron axon guidance  
acts_upstream_of_or_within motor neuron migration PubMed 
acts_upstream_of_or_within negative regulation of axon extension PubMed 
acts_upstream_of_or_within neuron migration PubMed 
acts_upstream_of_or_within nuclear migration PubMed 
acts_upstream_of_or_within positive regulation of axon extension PubMed 
involved_in positive regulation of axon extension  
involved_in positive regulation of cell motility  
involved_in positive regulation of cell motility  
acts_upstream_of_or_within positive regulation of glial cell proliferation PubMed 
acts_upstream_of_or_within regulation of cell migration PubMed 
acts_upstream_of_or_within regulation of glial cell migration PubMed 
involved_in regulation of synapse assembly PubMed 
involved_in regulation of synapse assembly PubMed 
involved_in regulation of synapse assembly PubMed 
involved_in substrate-dependent cell migration, cell extension  
involved_in substrate-dependent cell migration, cell extension  
involved_in tissue development  
Items 1 - 25 of 36
Component Evidence Code Pubs
located_in actin cytoskeleton  
located_in actin cytoskeleton  
is_active_in basement membrane  
located_in basement membrane PubMed 
located_in cell periphery PubMed 
located_in collagen-containing extracellular matrix PubMed 
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in extracellular region  
located_in extracellular region  
located_in extracellular region  
is_active_in glutamatergic synapse PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in synapse PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008744.2NP_032770.2  netrin-1 precursor

    See identical proteins and their annotated locations for NP_032770.2

    Status: VALIDATED

    Source sequence(s)
    AI840271, AL669842, BE652257, CF537666, CF585515, U65418
    Consensus CDS
    CCDS24864.1
    UniProtKB/Swiss-Prot
    B1ARR0, O09118, Q60832, Q9QY50
    Related
    ENSMUSP00000021284.3, ENSMUST00000021284.4
    Conserved Domains (4) summary
    smart00136
    Location:46283
    LamNT; Laminin N-terminal domain (domain VI)
    cd00055
    Location:403451
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:487601
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
    pfam00053
    Location:341394
    Laminin_EGF; Laminin EGF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68100190..68277652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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