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spat-3 E3 ubiquitin-protein ligase RING2 homolog spat-3 [ Caenorhabditis elegans ]

Gene ID: 259704, updated on 9-Dec-2024

Summary

Official Symbol
spat-3
Official Full Name
E3 ubiquitin-protein ligase RING2 homolog spat-3
Primary source
WormBase:WBGene00020496
Locus tag
CELE_T13H2.5
See related
AllianceGenome:WB:WBGene00020496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of gene expression, epigenetic; negative regulation of vulval development; and nematode male tail tip morphogenesis. Predicted to be part of PcG protein complex and ubiquitin ligase complex. Is expressed in several structures, including nervous system. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RING1 (ring finger protein 1) and RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See spat-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (4596011..4605928, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum junction formation protein lunapark;Endoplasmic reticulum junction formation protein lunapark-1 Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding  
enables histone ubiquitin ligase activity PubMed 
enables metal ion binding  
enables transferase activity  
enables ubiquitin protein ligase activity  
Component Evidence Code Pubs
part_of PcG protein complex  
part_of ubiquitin ligase complex  
part_of ubiquitin ligase complex  

General protein information

Preferred Names
E3 ubiquitin-protein ligase RING2 homolog spat-3
NP_001024904.2
  • Confirmed by transcript evidence
NP_001024905.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4596011..4605928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029733.6NP_001024904.2  E3 ubiquitin-protein ligase RING2 homolog spat-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024904.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KYH3, Q22463
    Conserved Domains (5) summary
    cd16544
    Location:158203
    RING-HC_RNF138; RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins
    pfam08226
    Location:21502199
    DUF1720; Domain of unknown function (DUF1720)
    pfam09770
    Location:17241845
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15782
    Location:13011430
    GREB1; Gene regulated by oestrogen in breast cancer
    NF012181
    Location:290583
    MSCRAMM_SdrD; MSCRAMM family adhesin SdrD
  2. NM_001029734.5NP_001024905.1  E3 ubiquitin-protein ligase RING2 homolog spat-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22463
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