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GstO3 Glutathione S transferase O3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38972, updated on 17-Dec-2024

Summary

Official Symbol
GstO3provided by FlyBase
Official Full Name
Glutathione S transferase O3provided by FlyBase
Primary source
FLYBASE:FBgn0035904
Locus tag
Dmel_CG6776
See related
AllianceGenome:FB:FBgn0035904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6776; Dmel\CG6776; DmGSTO3; GSTO3; T14
Summary
Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See GstO3 in Genome Data Viewer
Location:
66D5-66D5; 3-26 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8518885..8520295)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8511985..8513395)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Pseudouridine synthase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sepia Neighboring gene Glutathione S transferase O2 Neighboring gene Glutathione S transferase O1

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  

General protein information

Preferred Names
glutathione S transferase O3
Names
CG6776-PA
GstO3-PA
glutathione transferase
NP_648234.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8518885..8520295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139977.3NP_648234.1  glutathione S transferase O3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSL2
    Related
    FBpp0076348
    Conserved Domains (3) summary
    cd03184
    Location:109230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:22209
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:395
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
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