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WNT2B Wnt family member 2B [ Homo sapiens (human) ]

Gene ID: 7482, updated on 10-Dec-2024

Summary

Official Symbol
WNT2Bprovided by HGNC
Official Full Name
Wnt family member 2Bprovided by HGNC
Primary source
HGNC:HGNC:12781
See related
Ensembl:ENSG00000134245 MIM:601968; AllianceGenome:HGNC:12781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WNT13
Summary
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Broad expression in ovary (RPKM 4.3), skin (RPKM 3.1) and 21 other tissues See more
Orthologs
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Genomic context

See WNT2B in Genome Data Viewer
Location:
1p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112466541..112530165)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112479107..112542734)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113009163..113072787)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1195 Neighboring gene CTTNBP2 N-terminal like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:112947097-112947622 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:112950375-112950562 Neighboring gene Sharpr-MPRA regulatory region 6417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1513 Neighboring gene MPRA-validated peak369 silencer Neighboring gene microRNA 4256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113050855-113051398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1198 Neighboring gene Sharpr-MPRA regulatory region 8072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113052323-113052822 Neighboring gene suppression of tumorigenicity 7 like Neighboring gene MPRA-validated peak370 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1514 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:113161935-113163134 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diarrhea 9
MedGen: C4748517 OMIM: 618168 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity  
enables frizzled binding  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway  
involved_in canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway PubMed 
involved_in cell fate commitment  
involved_in cellular response to starvation  
involved_in chondrocyte differentiation PubMed 
involved_in cornea development in camera-type eye PubMed 
involved_in forebrain regionalization PubMed 
involved_in hematopoietic stem cell proliferation PubMed 
involved_in iris morphogenesis PubMed 
involved_in lens development in camera-type eye PubMed 
involved_in lung induction  
involved_in male gonad development PubMed 
involved_in mesenchymal-epithelial cell signaling  
involved_in neuron differentiation  
involved_in neuron differentiation  
involved_in positive regulation of branching involved in ureteric bud morphogenesis  

General protein information

Preferred Names
protein Wnt-2b
Names
XWNT2, Xenopus, homolog of
wingless-type MMTV integration site family, member 13
wingless-type MMTV integration site family, member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052953.2 RefSeqGene

    Range
    47426..68626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291880.1NP_001278809.1  protein Wnt-2b isoform 3

    See identical proteins and their annotated locations for NP_001278809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant WNT-2B2. The encoded isoform (3) has a shorter N-terminus, compared to isoform WNT-2B2.
    Source sequence(s)
    AK127449, BC141825
    Consensus CDS
    CCDS76188.1
    UniProtKB/TrEMBL
    Q5TEH8
    Related
    ENSP00000256640.5, ENST00000256640.9
    Conserved Domains (1) summary
    cl38924
    Location:1288
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
  2. NM_004185.4NP_004176.2  protein Wnt-2b isoform WNT-2B1

    See identical proteins and their annotated locations for NP_004176.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (WNT-2B1) differs in the 5' UTR and 5' coding region, compared to variant WNT-2B2. The encoded isoform (WNT-2B1) has a shorter and distinct N-terminus, compared to isoform WNT-2B2.
    Source sequence(s)
    AB045116, AK127449, BC141825
    Consensus CDS
    CCDS846.1
    UniProtKB/Swiss-Prot
    Q93097
    Related
    ENSP00000358700.4, ENST00000369686.9
    Conserved Domains (1) summary
    pfam00110
    Location:55361
    wnt; wnt family
  3. NM_024494.3NP_078613.1  protein Wnt-2b isoform WNT-2B2

    See identical proteins and their annotated locations for NP_078613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (WNT-2B2) represents the shortest transcript and encodes the longest isoform (WNT-2B2).
    Source sequence(s)
    AL109932, BC141825
    Consensus CDS
    CCDS847.1
    UniProtKB/Swiss-Prot
    O14903, Q5TEH9, Q5TEI2, Q93097, Q9HDC1, Q9HDC2
    Related
    ENSP00000358698.4, ENST00000369684.5
    Conserved Domains (1) summary
    pfam00110
    Location:74380
    wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    112466541..112530165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    112479107..112542734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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