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Lama5 laminin subunit alpha 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140433, updated on 27-Dec-2024

Summary

Official Symbol
Lama5provided by RGD
Official Full Name
laminin subunit alpha 5provided by RGD
Primary source
RGD:621023
See related
EnsemblRapid:ENSRNOG00000053691 AllianceGenome:RGD:621023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cell adhesion mediator activity; integrin binding activity; and receptor ligand activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including axon guidance; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including hair follicle development; morphogenesis of an epithelium; and trunk neural crest cell migration. Part of laminin-5 complex. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2 and familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 175.0), Lung (RPKM 146.2) and 9 other tissues See more
Orthologs
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Genomic context

See Lama5 in Genome Data Viewer
Location:
3q43
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187647904..187695974, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167270296..167318370, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175553042..175601112, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 2 Neighboring gene uncharacterized LOC120101831 Neighboring gene ADRM1 26S proteasome ubiquitin receptor Neighboring gene Cdk5 and Abl enzyme substrate 2 Neighboring gene ribosomal protein S21

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion mediator activity  
enables extracellular matrix structural constituent  
enables integrin binding  
enables receptor ligand activity  
Items 1 - 25 of 28
Process Evidence Code Pubs
involved_in animal organ morphogenesis  
acts_upstream_of_or_within animal organ morphogenesis  
involved_in axon guidance  
acts_upstream_of_or_within branching involved in salivary gland morphogenesis  
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis  
acts_upstream_of_or_within branching morphogenesis of an epithelial tube  
involved_in cell adhesion  
involved_in cell migration  
acts_upstream_of_or_within cilium assembly  
acts_upstream_of_or_within hair follicle development  
involved_in integrin-mediated signaling pathway  
acts_upstream_of_or_within kidney development  
acts_upstream_of_or_within lung development  
acts_upstream_of_or_within morphogenesis of a polarized epithelium  
acts_upstream_of_or_within morphogenesis of embryonic epithelium  
acts_upstream_of_or_within muscle organ development  
acts_upstream_of_or_within neural crest cell migration  
acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
involved_in postsynapse organization  
acts_upstream_of_or_within protein localization to plasma membrane  
involved_in regulation of cell adhesion  
involved_in regulation of cell migration  
involved_in regulation of embryonic development  
acts_upstream_of_or_within regulation of epithelial cell proliferation  
involved_in skeletal system morphogenesis  
involved_in substrate adhesion-dependent cell spreading  
involved_in tissue development  
acts_upstream_of_or_within trunk neural crest cell migration  
Items 1 - 25 of 28
Component Evidence Code Pubs
is_active_in basement membrane  
is_active_in basement membrane  
located_in basement membrane  
located_in extracellular matrix  
is_active_in extracellular matrix of synaptic cleft  
located_in extracellular space  
is_active_in glutamatergic synapse  
part_of laminin-10 complex  
part_of laminin-5 complex PubMed 
is_active_in neuromuscular junction  
is_active_in synaptic cleft  

General protein information

Preferred Names
laminin subunit alpha-5
Names
laminin, alpha 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191609.1NP_001178538.1  laminin subunit alpha-5 precursor

    See identical proteins and their annotated locations for NP_001178538.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A4V6, A6KMB1, F1MAN8
    Related
    ENSRNOP00000074084.1, ENSRNOT00000081226.3
    Conserved Domains (10) summary
    smart00180
    Location:499546
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:16891818
    LamB; Laminin B domain
    smart00282
    Location:31513269
    LamG; Laminin G domain
    cd00055
    Location:681723
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:35143663
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:15811629
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:58302
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06008
    Location:21892448
    Laminin_I; Laminin Domain I
    pfam06009
    Location:26392760
    Laminin_II; Laminin Domain II
    pfam12795
    Location:23972617
    MscS_porin; Mechanosensitive ion channel porin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    187647904..187695974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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