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Serf2 small EDRK-rich factor 2 [ Mus musculus (house mouse) ]

Gene ID: 378702, updated on 9-Dec-2024

Summary

Official Symbol
Serf2provided by MGI
Official Full Name
small EDRK-rich factor 2provided by MGI
Primary source
MGI:MGI:1337041
See related
Ensembl:ENSMUSG00000074884 AllianceGenome:MGI:1337041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msmac1l; m4F5rel
Summary
Predicted to be involved in protein destabilization. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including brain; endocrine gland; genitourinary system; oral epithelium; and respiratory system. Orthologous to human SERF2 (small EDRK-rich factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 128.1), large intestine adult (RPKM 95.4) and 28 other tissues See more
Orthologs
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Genomic context

See Serf2 in Genome Data Viewer
Location:
2 E5; 2 60.39 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121279679..121283901)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121449198..121453420)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene serine incorporator 4 Neighboring gene huntingtin interacting protein K Neighboring gene microfibrillar-associated protein 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
small EDRK-rich factor 2
Names
4F5rel (4F5 related)
protein 4F5-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290837.1NP_001277766.1  small EDRK-rich factor 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK132746, BP768998, BY070249, CJ073462
    Consensus CDS
    CCDS71126.1
    UniProtKB/TrEMBL
    A2ARQ4
    Related
    ENSMUSP00000097074.5, ENSMUST00000099475.12
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family
  2. NM_011354.3NP_035484.1  small EDRK-rich factor 2 isoform b

    See identical proteins and their annotated locations for NP_035484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK132746, BP768998, CJ073462
    Consensus CDS
    CCDS16645.1
    UniProtKB/Swiss-Prot
    A2ARQ3, P84102
    UniProtKB/TrEMBL
    Q58DZ4
    Related
    ENSMUSP00000123181.2, ENSMUST00000139253.8
    Conserved Domains (1) summary
    pfam04419
    Location:137
    4F5; 4F5 protein family

RNA

  1. NR_110986.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA423654, AK132746, BP768998, CJ073462

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121279679..121283901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)