U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    B4galt7 beta-1,4-galactosyltransferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 218271, updated on 4-Jan-2025

    Summary

    Official Symbol
    B4galt7provided by MGI
    Official Full Name
    beta-1,4-galactosyltransferase 7provided by MGI
    Primary source
    MGI:MGI:2384987
    See related
    Ensembl:ENSMUSG00000021504 AllianceGenome:MGI:2384987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XGPT; XGalT-1
    Summary
    Enables xylosylprotein 4-beta-galactosyltransferase activity. Involved in glycosaminoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 11.8), limb E14.5 (RPKM 11.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See B4galt7 in Genome Data Viewer
    Location:
    13 B1; 13 30.06 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55747709..55758258)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55599896..55610443)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31364 Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene calcium modulating ligand Neighboring gene DEAD box helicase 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC28643

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in glycosaminoglycan biosynthetic process PubMed 
    involved_in glycosaminoglycan biosynthetic process  
    involved_in glycosaminoglycan biosynthetic process  
    involved_in glycosylation  
    involved_in negative regulation of fibroblast proliferation  
    involved_in negative regulation of fibroblast proliferation  
    involved_in protein N-linked glycosylation  
    involved_in protein N-linked glycosylation  
    involved_in proteoglycan biosynthetic process  
    involved_in proteoglycan metabolic process  
    involved_in proteoglycan metabolic process  
    involved_in supramolecular fiber organization  
    involved_in supramolecular fiber organization  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    is_active_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi cisterna membrane  
    located_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    beta-1,4-galactosyltransferase 7
    Names
    UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7
    UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7
    UDP-galactose:beta-xylose beta-1,4-galactosyltransferase
    b4Gal-T7
    beta-1,4-GalTase 7
    beta4Gal-T7
    proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I
    xylosylprotein 4-beta-galactosyltransferase
    xylosylprotein beta-1,4-galactosyltransferase
    xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
    NP_001298066.1
    NP_666157.1
    XP_036013888.1
    XP_036013889.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311137.1NP_001298066.1  beta-1,4-galactosyltransferase 7 isoform 2

      See identical proteins and their annotated locations for NP_001298066.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      BC055703, BF455923
      Consensus CDS
      CCDS79190.1
      UniProtKB/TrEMBL
      Q3UR73
      Related
      ENSMUSP00000098327.4, ENSMUST00000100764.10
      Conserved Domains (1) summary
      cd00899
      Location:92280
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    2. NM_146045.2NP_666157.1  beta-1,4-galactosyltransferase 7 isoform 1

      See identical proteins and their annotated locations for NP_666157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK146855, BC055703, BF455923
      Consensus CDS
      CCDS26550.1
      UniProtKB/Swiss-Prot
      Q7TNU3, Q8R087
      UniProtKB/TrEMBL
      Q3TAW1, Q3UR73
      Related
      ENSMUSP00000068532.7, ENSMUST00000064701.8
      Conserved Domains (1) summary
      cd00899
      Location:92315
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55747709..55758258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157995.1XP_036013888.1  beta-1,4-galactosyltransferase 7 isoform X1

      UniProtKB/TrEMBL
      Q3UR73
      Related
      ENSMUSP00000123292.2, ENSMUST00000133176.8
      Conserved Domains (1) summary
      cd00899
      Location:36259
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    2. XM_036157996.1XP_036013889.1  beta-1,4-galactosyltransferase 7 isoform X2

      UniProtKB/TrEMBL
      D3Z065
      Conserved Domains (1) summary
      cd00899
      Location:36224
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
    External link. Please review our privacy policy.