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    Amh anti-Mullerian hormone [ Mus musculus (house mouse) ]

    Gene ID: 11705, updated on 4-Jan-2025

    Summary

    Official Symbol
    Amhprovided by MGI
    Official Full Name
    anti-Mullerian hormoneprovided by MGI
    Primary source
    MGI:MGI:88006
    See related
    Ensembl:ENSMUSG00000035262 AllianceGenome:MGI:88006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIS
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Homozygous knockout male mice develop female reproductive organs and are often sterile, while homozygous knockout female mice exhibit premature depletion of primordial follicles. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in ovary adult (RPKM 123.7) and stomach adult (RPKM 9.9) See more
    Orthologs
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    Genomic context

    See Amh in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80641074..80643513)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80805240..80807679)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene splicing factor 3a, subunit 2 Neighboring gene Amh promoter region Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene STARR-seq mESC enhancer starr_27299 Neighboring gene STARR-positive B cell enhancer ABC_E369 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene microRNA 1982

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (10)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Leydig cell differentiation PubMed 
    involved_in Mullerian duct regression  
    involved_in Mullerian duct regression  
    involved_in Mullerian duct regression  
    involved_in anti-Mullerian hormone receptor signaling pathway  
    involved_in anti-Mullerian hormone receptor signaling pathway  
    involved_in gonadal mesoderm development  
    involved_in negative regulation of ovarian follicle development PubMed 
    involved_in negative regulation of ovarian follicle development  
    involved_in ovarian follicle development PubMed 
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of gene expression  
    involved_in preantral ovarian follicle growth  
    involved_in sex determination PubMed 
    acts_upstream_of_or_within urogenital system development  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    muellerian-inhibiting factor
    Names
    Mullerian inhibiting substance
    anti-Muellerian hormone
    muellerian-inhibiting substance

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007445.3NP_031471.2  muellerian-inhibiting factor precursor

      See identical proteins and their annotated locations for NP_031471.2

      Status: REVIEWED

      Source sequence(s)
      AC166937
      Consensus CDS
      CCDS24033.1
      UniProtKB/Swiss-Prot
      A7E2R1, P27106, Q5EC55
      UniProtKB/TrEMBL
      A0A8Q0P8A2
      Related
      ENSMUSP00000043153.5, ENSMUST00000036016.6
      Conserved Domains (2) summary
      smart00204
      Location:456554
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam04709
      Location:76396
      AMH_N; Anti-Mullerian hormone, N terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80641074..80643513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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