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TWF2 twinfilin actin binding protein 2 [ Homo sapiens (human) ]

Gene ID: 11344, updated on 4-Jan-2025

Summary

Official Symbol
TWF2provided by HGNC
Official Full Name
twinfilin actin binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9621
See related
Ensembl:ENSG00000247596 MIM:607433; AllianceGenome:HGNC:9621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A6r; A6RP; PTK9L; MSTP011
Summary
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 28.1), heart (RPKM 27.1) and 25 other tissues See more
Orthologs
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Genomic context

See TWF2 in Genome Data Viewer
Location:
3p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52228612..52239158, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52261498..52272045, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52262628..52273174, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14432 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene Sharpr-MPRA regulatory region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52259793-52260294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:52260295-52260794 Neighboring gene toll like receptor 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14433 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52270765-52271306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52271307-52271849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19933 Neighboring gene NANOG hESC enhancer GRCh37_chr3:52274848-52275376 Neighboring gene TWF2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14436 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Interactions

General gene information

Potential readthrough

Included gene: TLR9

Clone Names

  • FLJ56277

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding PubMed 
enables RNA binding PubMed 
enables actin filament binding  
enables actin monomer binding  
enables actin monomer binding PubMed 
enables cadherin binding PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding PubMed 
enables protein binding PubMed 
enables protein kinase C binding PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization  
involved_in barbed-end actin filament capping  
involved_in barbed-end actin filament capping PubMed 
involved_in cell projection organization  
involved_in cellular response to growth factor stimulus PubMed 
involved_in cellular response to retinoic acid PubMed 
involved_in negative regulation of actin filament polymerization PubMed 
involved_in positive regulation of axon extension PubMed 
involved_in positive regulation of lamellipodium assembly PubMed 
involved_in positive regulation of neuron projection development  
involved_in positive regulation of neuron projection development PubMed 
involved_in regulation of actin cytoskeleton organization PubMed 
involved_in regulation of lamellipodium assembly  
involved_in regulation of microvillus length PubMed 
involved_in sequestering of actin monomers  
involved_in sequestering of actin monomers PubMed 
Component Evidence Code Pubs
is_active_in actin filament  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in extracellular exosome PubMed 
located_in filopodium PubMed 
located_in growth cone PubMed 
located_in lamellipodium PubMed 
is_active_in myofibril  
located_in myofibril PubMed 
located_in perinuclear region of cytoplasm PubMed 
located_in stereocilium PubMed 

General protein information

Preferred Names
twinfilin-2
Names
A6-related protein
PTK9L protein tyrosine kinase 9-like (A6-related protein)
protein tyrosine kinase 9-like (A6-related protein)
twinfilin, actin-binding protein, homolog 2
twinfilin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007284.4NP_009215.1  twinfilin-2

    See identical proteins and their annotated locations for NP_009215.1

    Status: REVIEWED

    Source sequence(s)
    AL136773, BC003161, BI551353
    Consensus CDS
    CCDS2849.1
    UniProtKB/Swiss-Prot
    Q6IBS0, Q9Y3F5
    UniProtKB/TrEMBL
    A0A7I2V2U8
    Related
    ENSP00000303908.4, ENST00000305533.10
    Conserved Domains (2) summary
    cd11284
    Location:176311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    52228612..52239158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    52261498..52272045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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