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    jmjc-1 Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [ Caenorhabditis elegans ]

    Gene ID: 171932, updated on 4-Jan-2025

    Summary

    Official Symbol
    jmjc-1
    Official Full Name
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
    Primary source
    WormBase:WBGene00020902
    Locus tag
    CELE_T28F2.4
    See related
    AllianceGenome:WB:WBGene00020902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable histone H3K36 demethylase activity; histone H3K4me/H3K4me2/H3K4me3 demethylase activity; and iron ion binding activity. Involved in several processes, including response to ethanol; response to heat; and response to osmotic stress. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human RIOX1 (ribosomal oxygenase 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See jmjc-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (3631091..3636485, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Seven cysteines N-terminal domain-containing protein Neighboring gene Carbonic anhydrase Neighboring gene Protein LAZ1;Vacuolar protein sorting-associated protein 13D Neighboring gene tRNA-Met

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity  
    enables dioxygenase activity  
    enables histone H3K36 demethylase activity  
    enables histone H3K36 demethylase activity  
    enables histone H3K36me/H3K36me2 demethylase activity  
    enables histone H3K4 demethylase activity  
    enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity  
    enables iron ion binding  
    enables metal ion binding  
    Process Evidence Code Pubs
    involved_in chromatin organization  
    involved_in chromatin remodeling  
    involved_in negative regulation of DNA-templated transcription  
    involved_in response to ethanol PubMed 
    involved_in response to heat PubMed 
    involved_in response to osmotic stress PubMed 
    involved_in response to oxidative stress PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
    NP_001021644.1
    • Confirmed by transcript evidence
    NP_001021645.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3631091..3636485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026473.7NP_001021644.1  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G8XYY5, O01658
      Conserved Domains (1) summary
      pfam08007
      Location:317662
      Cupin_4; Cupin superfamily protein
    2. NM_001026474.4NP_001021645.1  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01658
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