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PLD6 phospholipase D family member 6 [ Homo sapiens (human) ]

Gene ID: 201164, updated on 4-Jan-2025

Summary

Official Symbol
PLD6provided by HGNC
Official Full Name
phospholipase D family member 6provided by HGNC
Primary source
HGNC:HGNC:30447
See related
Ensembl:ENSG00000179598 MIM:614960; AllianceGenome:HGNC:30447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZUC
Summary
Enables cardiolipin hydrolase activity and protein homodimerization activity. Involved in mitochondrial fusion. Acts upstream of or within positive regulation of mitochondrial fusion. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis (RPKM 12.6), prostate (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See PLD6 in Genome Data Viewer
Location:
17p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (17200995..17206333, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (17147036..17152468, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17104309..17109647, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene myosin phosphatase Rho interacting protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17074887-17075546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17075547-17076206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11790 Neighboring gene RNA, U6 small nuclear 767, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17088115-17088615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11791 Neighboring gene RNA, 7SL, cytoplasmic 775, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17094445-17095112 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17095113-17095778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17109841-17110680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17132411-17132910 Neighboring gene folliculin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11794 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17141243-17141428 Neighboring gene actin gamma 1 pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in P granule organization  
involved_in lipid catabolic process  
involved_in meiotic cell cycle  
involved_in mitochondrial fusion PubMed 
involved_in mitochondrial fusion PubMed 
involved_in piRNA processing  
acts_upstream_of_or_within positive regulation of mitochondrial fusion PubMed 
involved_in spermatid development  
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in mitochondrial outer membrane PubMed 
located_in mitochondrial outer membrane  
located_in mitochondrion PubMed 
is_active_in mitochondrion  

General protein information

Preferred Names
mitochondrial cardiolipin hydrolase
Names
PLD 6
Zucchini endoribonuclease
choline phosphatase 6
mitoPLD
mitochondrial phospholipase
phosphatidylcholine-hydrolyzing phospholipase D6
phospholipase D6
protein zucchini homolog
NP_849158.2
XP_016879799.3
XP_054171326.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178836.4NP_849158.2  mitochondrial cardiolipin hydrolase

    See identical proteins and their annotated locations for NP_849158.2

    Status: VALIDATED

    Source sequence(s)
    AC055811, AK090899, BC031263, DC326979
    Consensus CDS
    CCDS11182.1
    UniProtKB/Swiss-Prot
    Q8N2A8, Q8N5Y1
    Related
    ENSP00000317177.3, ENST00000321560.4
    Conserved Domains (2) summary
    cd09171
    Location:95206
    PLDc_vPLD6_like; Catalytic domain of vertebrate phospholipase D6 and similar proteins
    pfam13091
    Location:95206
    PLDc_2; PLD-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    17200995..17206333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024310.3XP_016879799.3  mitochondrial cardiolipin hydrolase isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    17147036..17152468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315351.1XP_054171326.1  mitochondrial cardiolipin hydrolase isoform X2

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