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DDIT4 DNA damage inducible transcript 4 [ Homo sapiens (human) ]

Gene ID: 54541, updated on 4-Jan-2025

Summary

Official Symbol
DDIT4provided by HGNC
Official Full Name
DNA damage inducible transcript 4provided by HGNC
Primary source
HGNC:HGNC:24944
See related
Ensembl:ENSG00000168209 MIM:607729; AllianceGenome:HGNC:24944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dig2; REDD1; REDD-1
Summary
Predicted to enable 14-3-3 protein binding activity. Involved in negative regulation of TOR signaling and response to hypoxia. Located in cytosol. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in ovary (RPKM 89.7), fat (RPKM 84.2) and 25 other tissues See more
Orthologs
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Genomic context

See DDIT4 in Genome Data Viewer
Location:
10q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (72273924..72276036)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (73144950..73147062)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74033682..74035794)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73975455-73976450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73977030-73977571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74007658-74008225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008226-74008794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008795-74009361 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene Sharpr-MPRA regulatory region 8691 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74020023-74020666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030210-74030710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030711-74031211 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032179-74032702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032703-74033226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:74035325-74035848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74046277-74046777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2471 Neighboring gene DDIT4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2472 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74057879-74058535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:74069939-74070924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2473 Neighboring gene Sharpr-MPRA regulatory region 14427 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:74081426-74082625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74084563-74085524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3549 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 Neighboring gene RNA, U6 small nuclear 805, pseudogene Neighboring gene mitochondrial calcium uptake 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ20500

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in apoptotic process  
involved_in brain development  
involved_in cellular response to dexamethasone stimulus  
involved_in defense response to virus PubMed 
involved_in intracellular signal transduction  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
involved_in negative regulation of TOR signaling  
involved_in negative regulation of TOR signaling PubMed 
involved_in negative regulation of glycolytic process  
involved_in neuron differentiation  
involved_in neuron migration  
involved_in neurotrophin TRK receptor signaling pathway  
involved_in protein-containing complex disassembly  
involved_in reactive oxygen species metabolic process  
involved_in response to hypoxia  
involved_in response to hypoxia PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in mitochondrion  

General protein information

Preferred Names
DNA damage-inducible transcript 4 protein
Names
HIF-1 responsive protein RTP801
protein regulated in development and DNA damage response 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019058.4NP_061931.1  DNA damage-inducible transcript 4 protein

    See identical proteins and their annotated locations for NP_061931.1

    Status: VALIDATED

    Source sequence(s)
    AF335324, BC007714, BC015236, BE882343
    Consensus CDS
    CCDS7315.1
    UniProtKB/Swiss-Prot
    Q9H0S3, Q9NX09
    Related
    ENSP00000307305.3, ENST00000307365.4
    Conserved Domains (1) summary
    pfam07809
    Location:104223
    RTP801_C; RTP801 C-terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    72273924..72276036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    73144950..73147062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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