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CG13690 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33213, updated on 4-Jan-2025

Summary

Official Symbol
CG13690provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0031252
Locus tag
Dmel_CG13690
See related
AllianceGenome:FB:FBgn0031252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG13690
Summary
Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See CG13690 in Genome Data Viewer
Location:
21C2-21C2; 2-0.7 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (418434..419652, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (418434..419652, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RNA polymerase I subunit B Neighboring gene Adaptor Protein complex 2, alpha subunit Neighboring gene ebi Neighboring gene Ribosomal protein LP1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding  
enables RNA-DNA hybrid ribonuclease activity  
enables RNA-DNA hybrid ribonuclease activity  
Process Evidence Code Pubs
involved_in DNA replication, removal of RNA primer  
involved_in RNA metabolic process  
involved_in mismatch repair  
Component Evidence Code Pubs
part_of ribonuclease H2 complex  

General protein information

Preferred Names
uncharacterized protein
Names
CG13690-PA
NP_608521.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    418434..419652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134677.4NP_608521.1  uncharacterized protein Dmel_CG13690 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608521.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V3V1, Q9VPP5
    UniProtKB/TrEMBL
    A0AP92, A0AP98, A0APA0, C0MJM8, C0MJN4, C0MJN5, C0MJN7
    Related
    FBpp0077750
    Conserved Domains (1) summary
    cd07181
    Location:73295
    RNase_HII_eukaryota_like; Eukaryotic RNase HII
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