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Fscn3 fascin actin-bundling protein 3 [ Mus musculus (house mouse) ]

Gene ID: 56223, updated on 4-Jan-2025

Summary

Official Symbol
Fscn3provided by MGI
Official Full Name
fascin actin-bundling protein 3provided by MGI
Primary source
MGI:MGI:1890386
See related
Ensembl:ENSMUSG00000029707 AllianceGenome:MGI:1890386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to act upstream of or within spermatid development. Located in cytoplasm. Is expressed in testis. Orthologous to human FSCN3 (fascin actin-bundling protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis adult (RPKM 130.6) See more
Orthologs
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Genomic context

See Fscn3 in Genome Data Viewer
Location:
6 A3.3; 6 11.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (28427888..28438621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (28427870..28438622)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 800 Neighboring gene STARR-seq mESC enhancer starr_15409 Neighboring gene kelch domain containing pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:28371614-28371915 Neighboring gene Pax4 5' regulatory region Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:28430124-28430311 Neighboring gene golgi coiled coil 1 Neighboring gene ARF GTPase 5 Neighboring gene paired box 4 Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_15418 Neighboring gene leucine rich repeat containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding PubMed 
enables actin binding  
enables actin filament binding  
enables actin filament binding  
enables protein-macromolecule adaptor activity  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization  
involved_in actin filament bundle assembly  
involved_in actin filament organization  
involved_in cell migration  
involved_in establishment or maintenance of cell polarity  
acts_upstream_of_or_within spermatid development PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton  
located_in actin cytoskeleton  
is_active_in cell projection membrane  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in filopodium  
is_active_in growth cone  
is_active_in lamellipodium  
is_active_in microvillus  
is_active_in ruffle  

General protein information

Preferred Names
fascin-3
Names
fascin (testis)
fascin homolog 3, actin-bundling protein, testicular
testis fascin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411255.1NP_001398184.1  fascin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068608
  2. NM_019569.3NP_062515.2  fascin-3 isoform 1

    See identical proteins and their annotated locations for NP_062515.2

    Status: VALIDATED

    Source sequence(s)
    AC068608
    Consensus CDS
    CCDS39446.1
    UniProtKB/Swiss-Prot
    Q80YU6, Q9QXW4
    Related
    ENSMUSP00000031719.7, ENSMUST00000031719.7
    Conserved Domains (2) summary
    cd00257
    Location:263381
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:24138
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    28427888..28438621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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