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Cbx7 chromobox 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362962, updated on 4-Jan-2025

Summary

Official Symbol
Cbx7provided by RGD
Official Full Name
chromobox 7provided by RGD
Primary source
RGD:735027
See related
EnsemblRapid:ENSRNOG00000016875 AllianceGenome:RGD:735027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Involved in developmental process involved in reproduction; positive regulation of transcription elongation by RNA polymerase II; and response to xenobiotic stimulus. Predicted to be located in cytosol; heterochromatin; and nucleoplasm. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 91.5), Lung (RPKM 84.5) and 9 other tissues See more
Orthologs
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Genomic context

See Cbx7 in Genome Data Viewer
Location:
7q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113341030..113358716, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111460656..111479231, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121136067..121153503, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547383 Neighboring gene U6 spliceosomal RNA Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3 Neighboring gene uncharacterized LOC120093692 Neighboring gene small nucleolar RNA U109 Neighboring gene platelet derived growth factor subunit B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding  
enables methylated histone binding  
enables single-stranded RNA binding  
Component Evidence Code Pubs
part_of PRC1 complex  
part_of PRC1 complex  
part_of PRC1 complex  
part_of PcG protein complex  
part_of PcG protein complex  
located_in chromatin  
located_in chromatin  
located_in cytosol  
located_in cytosol  
located_in heterochromatin  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  

General protein information

Preferred Names
chromobox protein homolog 7
Names
chromobox homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199117.2NP_954548.1  chromobox protein homolog 7

    See identical proteins and their annotated locations for NP_954548.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P60889
    UniProtKB/TrEMBL
    A6HSV0
    Conserved Domains (1) summary
    pfam00385
    Location:1360
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    113341030..113358716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079593.2XP_038935521.1  chromobox protein homolog 7 isoform X7

    UniProtKB/TrEMBL
    A0A8L2UR72
    Related
    ENSRNOP00000074584.2, ENSRNOT00000077731.3
  2. XM_039079592.2XP_038935520.1  chromobox protein homolog 7 isoform X6

    Conserved Domains (2) summary
    cd18646
    Location:762
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:115146
    CBX7_C; CBX family C-terminal motif
  3. XM_039079591.2XP_038935519.1  chromobox protein homolog 7 isoform X4

    Conserved Domains (2) summary
    cd18646
    Location:762
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:150181
    CBX7_C; CBX family C-terminal motif
  4. XM_006242022.5XP_006242084.1  chromobox protein homolog 7 isoform X2

    Conserved Domains (1) summary
    smart00298
    Location:1062
    CHROMO; Chromatin organization modifier domain
  5. XM_006242020.5XP_006242082.1  chromobox protein homolog 7 isoform X1

    See identical proteins and their annotated locations for XP_006242082.1

    UniProtKB/TrEMBL
    A0A8L2QCQ7, A6HSV1
    Related
    ENSRNOP00000022631.6, ENSRNOT00000022631.8
    Conserved Domains (1) summary
    smart00298
    Location:1062
    CHROMO; Chromatin organization modifier domain
  6. XM_039079590.2XP_038935518.1  chromobox protein homolog 7 isoform X3

    Conserved Domains (1) summary
    pfam17218
    Location:155186
    CBX7_C; CBX family C-terminal motif
  7. XM_063263925.1XP_063119995.1  chromobox protein homolog 7 isoform X5

  8. XM_006242021.5XP_006242083.1  chromobox protein homolog 7 isoform X1

    See identical proteins and their annotated locations for XP_006242083.1

    UniProtKB/TrEMBL
    A0A8L2QCQ7, A6HSV1
    Conserved Domains (1) summary
    smart00298
    Location:1062
    CHROMO; Chromatin organization modifier domain
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