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SIGLEC16 sialic acid binding Ig like lectin 16 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 400709, updated on 4-Jan-2025

Summary

Official Symbol
SIGLEC16provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 16 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:24851
See related
Ensembl:ENSG00000161643 AllianceGenome:HGNC:24851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIGLECP16; Siglec-P16
Summary
Predicted to enable sialic acid binding activity. Involved in positive regulation of defense response to bacterium and positive regulation of interleukin-6 production. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Biased expression in ovary (RPKM 40.2) and spleen (RPKM 10.4) See more
Orthologs
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Genomic context

See SIGLEC16 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49969664..49975814)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52969773..52975922)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50472921..50479071)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene sialic acid binding Ig like lectin 11 Neighboring gene uncharacterized LOC124904745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50474918-50475418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14970 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50490479-50490646 Neighboring gene VRK serine/threonine kinase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50497521-50498022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50498023-50498522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50527935-50528436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14973 Neighboring gene zinc finger protein 473 Neighboring gene uncharacterized LOC124904744

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding  
enables protein binding PubMed 
enables sialic acid binding  
Component Evidence Code Pubs
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 16
Names
sialic acid binding Ig-like lectin 16
sialic acid binding Ig-like lectin, pseudogene 16
sialic acid-binding immunoglobulin-like lectin 16
siglec-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348364.2NP_001335293.2  sialic acid-binding Ig-like lectin 16 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the functional allele encoding the full-length protein.
    Source sequence(s)
    AC011452, AK301031, BC030222
    UniProtKB/Swiss-Prot
    A6NMB1
    Related
    ENSP00000502223.2, ENST00000602139.6
    Conserved Domains (2) summary
    cd05712
    Location:22141
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:247323
    IG_like; Immunoglobulin like

RNA

  1. NR_145574.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, noncoding) represents the reference genome allele, which does not encode a full-length protein and is predicted to be non-functional.
    Source sequence(s)
    AC011452, AK301031, BC030222

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49969664..49975814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52969773..52975922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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