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    Klf5 Kruppel-like transcription factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 12224, updated on 4-Jan-2025

    Summary

    Official Symbol
    Klf5provided by MGI
    Official Full Name
    Kruppel-like transcription factor 5provided by MGI
    Primary source
    MGI:MGI:1338056
    See related
    Ensembl:ENSMUSG00000005148 AllianceGenome:MGI:1338056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CKLF; IKLF; Bteb2; 4930520J07Rik
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific; MRF binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and skeletal muscle tissue regeneration. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in colon adult (RPKM 291.0), duodenum adult (RPKM 159.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Klf5 in Genome Data Viewer
    Location:
    14 E2.2; 14 49.43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99536127..99550848)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99298691..99313412)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene bora, aurora kinase A activator Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene STARR-seq mESC enhancer starr_37436 Neighboring gene STARR-seq mESC enhancer starr_37437 Neighboring gene STARR-seq mESC enhancer starr_37440 Neighboring gene predicted gene, 22984 Neighboring gene predicted gene, 25130

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation
    • Targeted (10)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables MRF binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis PubMed 
    involved_in cell-cell signaling via exosome  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    involved_in cellular response to organic cyclic compound  
    involved_in cellular response to peptide  
    acts_upstream_of_or_within intestinal epithelial cell development PubMed 
    acts_upstream_of microvillus assembly PubMed 
    acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration PubMed 
    acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of fat cell differentiation PubMed 
    involved_in positive regulation of miRNA transcription  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by transcription factor localization PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of regulation of microvillus assembly PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within satellite cell activation involved in skeletal muscle regeneration PubMed 
    acts_upstream_of_or_within skeletal muscle cell differentiation PubMed 
    acts_upstream_of_or_within skeletal muscle satellite cell differentiation PubMed 
    acts_upstream_of_or_within skeletal muscle tissue regeneration PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 5
    Names
    BTE-binding protein 2
    Kruppel-like factor 5
    basic transcription element-binding protein 2
    intestinal-enriched krueppel-like factor
    transcription factor BTEB2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009769.4NP_033899.2  Krueppel-like factor 5

      See identical proteins and their annotated locations for NP_033899.2

      Status: PROVISIONAL

      Source sequence(s)
      AC165154
      Consensus CDS
      CCDS27311.1
      UniProtKB/Swiss-Prot
      Q9JMI2, Q9Z0Z7
      Related
      ENSMUSP00000005279.7, ENSMUST00000005279.8
      Conserved Domains (3) summary
      COG5048
      Location:338422
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:408433
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      99536127..99550848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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