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    PDPK1 3-phosphoinositide dependent protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5170, updated on 4-Jan-2025

    Summary

    Official Symbol
    PDPK1provided by HGNC
    Official Full Name
    3-phosphoinositide dependent protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:8816
    See related
    Ensembl:ENSG00000140992 MIM:605213; AllianceGenome:HGNC:8816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDK1; PDPK2; PDPK2P; PRO0461
    Summary
    Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of protein kinase activity; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
    Expression
    Ubiquitous expression in brain (RPKM 5.6), testis (RPKM 5.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PDPK1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2538021..2603188)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2560174..2625339)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2588022..2653189)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene amidohydrolase domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2582640-2583341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2588417-2589117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10274 Neighboring gene microRNA 3178 Neighboring gene cementum protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2607343-2607844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2610177-2610678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2610679-2611178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2635245-2635746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10275 Neighboring gene potassium channel tetramerization domain containing 5 pseudogene Neighboring gene 3-phosphoinositide dependent protein kinase 2, pseudogene Neighboring gene uncharacterized LOC645644

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat A Coumarin derivative BPRHIV001 modulates HIV-1 Tat function through a reduction of the phosphorylated PDPK1 protein level PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC20087, MGC35290

    Gene Ontology Provided by GOA

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity PubMed 
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables phospholipase activator activity PubMed 
    enables phospholipase binding PubMed 
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 29
    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in T cell costimulation  
    involved_in actin cytoskeleton organization PubMed 
    involved_in activation of protein kinase B activity PubMed 
    involved_in calcium-mediated signaling PubMed 
    involved_in cell migration PubMed 
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to insulin stimulus PubMed 
    involved_in chromatin remodeling  
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in extrinsic apoptotic signaling pathway PubMed 
    involved_in hyperosmotic response  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within intracellular signal transduction PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of endothelial cell apoptotic process PubMed 
    involved_in negative regulation of protein kinase activity PubMed 
    involved_in negative regulation of toll-like receptor signaling pathway  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phospholipase activity PubMed 
    involved_in positive regulation of protein localization to plasma membrane PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
    involved_in positive regulation of sprouting angiogenesis PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in regulation of mast cell degranulation  
    involved_in type B pancreatic cell development  
    Items 1 - 25 of 34
    Component Evidence Code Pubs
    located_in cell projection PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in focal adhesion  
    located_in membrane  
    located_in nucleus  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic density  

    General protein information

    Preferred Names
    3-phosphoinositide-dependent protein kinase 1
    Names
    3-phosphoinositide-dependent protein kinase 2 pseudogene
    PkB kinase like gene 1
    Putative 3-phosphoinositide-dependent protein kinase 2
    NP_001248745.1
    NP_002604.1
    NP_112558.2
    XP_011520823.1
    XP_011520825.1
    XP_024306064.1
    XP_047290154.1
    XP_047290155.1
    XP_047290156.1
    XP_047290157.1
    XP_047290158.1
    XP_054236418.1
    XP_054236419.1
    XP_054236420.1
    XP_054236421.1
    XP_054236422.1
    XP_054236423.1
    XP_054236424.1
    XP_054236425.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261816.2NP_001248745.1  3-phosphoinositide-dependent protein kinase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB209835, AC141586
      Consensus CDS
      CCDS58411.1
      UniProtKB/TrEMBL
      Q9UPJ8
      Related
      ENSP00000395357.3, ENST00000441549.7
      Conserved Domains (1) summary
      cd05581
      Location:80342
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    2. NM_002613.5NP_002604.1  3-phosphoinositide-dependent protein kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_002604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC141586, BC012103
      Consensus CDS
      CCDS10472.1
      UniProtKB/Swiss-Prot
      H0Y4Z0, O15530, Q59EH6, Q6FI20, Q8IV52, Q9BRD5
      UniProtKB/TrEMBL
      Q53HJ9
      Related
      ENSP00000344220.4, ENST00000342085.9
      Conserved Domains (2) summary
      cd01262
      Location:441547
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:80342
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    3. NM_031268.6NP_112558.2  3-phosphoinositide-dependent protein kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_112558.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC093525, AC141586, BC033494
      Consensus CDS
      CCDS10473.1
      UniProtKB/Swiss-Prot
      O15530
      Related
      ENSP00000268673.7, ENST00000268673.12
      Conserved Domains (2) summary
      cd01262
      Location:314420
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cl21453
      Location:81215
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2538021..2603188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434200.1XP_047290156.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      E9PER6, Q53HJ9
    2. XM_024450296.2XP_024306064.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      E9PER6, Q53HJ9
      Related
      ENSP00000373876.3, ENST00000389224.7
      Conserved Domains (2) summary
      cd01262
      Location:414520
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:53315
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    3. XM_047434199.1XP_047290155.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      E9PER6, Q53HJ9
    4. XM_047434202.1XP_047290158.1  3-phosphoinositide-dependent protein kinase 1 isoform X6

    5. XM_011522523.4XP_011520825.1  3-phosphoinositide-dependent protein kinase 1 isoform X4

      Conserved Domains (2) summary
      cd01262
      Location:348454
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cl21453
      Location:115249
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011522521.4XP_011520823.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q53HJ9
      Conserved Domains (3) summary
      smart00220
      Location:116376
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:475581
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:114376
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    7. XM_047434198.1XP_047290154.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      Q53HJ9
    8. XM_047434201.1XP_047290157.1  3-phosphoinositide-dependent protein kinase 1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2560174..2625339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380447.1XP_054236422.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      E9PER6, Q53HJ9
    2. XM_054380446.1XP_054236421.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      E9PER6, Q53HJ9
    3. XM_054380445.1XP_054236420.1  3-phosphoinositide-dependent protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      E9PER6, Q53HJ9
    4. XM_054380444.1XP_054236419.1  3-phosphoinositide-dependent protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      Q53HJ9
    5. XM_054380443.1XP_054236418.1  3-phosphoinositide-dependent protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q53HJ9
    6. XM_054380448.1XP_054236423.1  3-phosphoinositide-dependent protein kinase 1 isoform X4

    7. XM_054380450.1XP_054236425.1  3-phosphoinositide-dependent protein kinase 1 isoform X6

    8. XM_054380449.1XP_054236424.1  3-phosphoinositide-dependent protein kinase 1 isoform X5

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