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Ptp4a3 protein tyrosine phosphatase 4A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362930, updated on 4-Jan-2025

Summary

Official Symbol
Ptp4a3provided by RGD
Official Full Name
protein tyrosine phosphatase 4A3provided by RGD
Primary source
RGD:1308687
See related
EnsemblRapid:ENSRNOG00000007628 AllianceGenome:RGD:1308687
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in several processes, including endothelial cell migration; positive regulation of establishment of protein localization; and positive regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of vascular permeability; and regulation of vascular endothelial growth factor signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A3 (protein tyrosine phosphatase 4A3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 596.4), Heart (RPKM 272.7) and 4 other tissues See more
Orthologs
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Genomic context

See Ptp4a3 in Genome Data Viewer
Location:
7q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (107518220..107549949)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (105650640..105660921)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (114969699..115002902)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479924 Neighboring gene G protein-coupled receptor 20 Neighboring gene U4 spliceosomal RNA Neighboring gene maestro heat-like repeat family member 5 Neighboring gene ribosomal protein L29 like 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
is_active_in nucleus  
located_in nucleus  

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 3
Names
protein tyrosine phosphatase type IVA, member 3
NP_001107877.1
XP_006241791.1
XP_006241793.1
XP_006241794.1
XP_008763795.1
XP_008763796.1
XP_063119925.1
XP_063119926.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114405.2NP_001107877.1  protein tyrosine phosphatase type IVA 3

    See identical proteins and their annotated locations for NP_001107877.1

    Status: PROVISIONAL

    Source sequence(s)
    BC159432
    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    107518220..107549949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263855.1XP_063119925.1  protein tyrosine phosphatase type IVA 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
  2. XM_063263856.1XP_063119926.1  protein tyrosine phosphatase type IVA 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
  3. XM_008765573.4XP_008763795.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_008763795.1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_006241731.5XP_006241793.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_006241793.1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. XM_008765574.4XP_008763796.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_008763796.1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  6. XM_006241729.5XP_006241791.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_006241791.1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
    Related
    ENSRNOP00000078100.1, ENSRNOT00000096141.2
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  7. XM_006241732.5XP_006241794.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_006241794.1

    UniProtKB/TrEMBL
    A0A8I5Y855, B0K032, F7EWD1
    Conserved Domains (1) summary
    cl28904
    Location:5158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
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