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S100P S100 calcium binding protein P [ Homo sapiens (human) ]

Gene ID: 6286, updated on 4-Jan-2025

Summary

Official Symbol
S100Pprovided by HGNC
Official Full Name
S100 calcium binding protein Pprovided by HGNC
Primary source
HGNC:HGNC:10504
See related
Ensembl:ENSG00000163993 MIM:600614; AllianceGenome:HGNC:10504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIG9
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 580.8), bone marrow (RPKM 258.6) and 4 other tissues See more
Orthologs
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Genomic context

See S100P in Genome Data Viewer
Location:
4p16.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (6693878..6697170)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (6668946..6672248)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6695605..6698897)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15235 Neighboring gene Morf4 family associated protein 1 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6684859-6685361 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6685913-6686414 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:6690316-6691515 Neighboring gene long intergenic non-protein coding RNA 2481 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6694289-6694826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695136-6695872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:6695873-6696608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:6697811-6698573 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:6710044-6711243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21261 Neighboring gene Morf4 family associated protein 1 like 1 Neighboring gene uncharacterized LOC105378240

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding PubMed 
enables calcium ion binding  
enables calcium-dependent protein binding  
enables calcium-dependent protein binding PubMed 
enables magnesium ion binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables transition metal ion binding  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in extracellular exosome PubMed 
located_in extracellular region  
located_in microvillus membrane  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in secretory granule lumen  

General protein information

Preferred Names
protein S100-P
Names
migration-inducing gene 9 protein
protein S100-E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005980.3NP_005971.1  protein S100-P

    See identical proteins and their annotated locations for NP_005971.1

    Status: REVIEWED

    Source sequence(s)
    AC093323, KF495696
    Consensus CDS
    CCDS3391.1
    UniProtKB/Swiss-Prot
    P25815, Q5J7W2
    Related
    ENSP00000296370.3, ENST00000296370.4
    Conserved Domains (1) summary
    cd00213
    Location:289
    S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    6693878..6697170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    6668946..6672248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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