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Wnt7b wingless-type MMTV integration site family, member 7B [ Mus musculus (house mouse) ]

Gene ID: 22422, updated on 7-Jan-2025

Summary

Official Symbol
Wnt7bprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 7Bprovided by MGI
Primary source
MGI:MGI:98962
See related
Ensembl:ENSMUSG00000022382 AllianceGenome:MGI:98962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-7b
Summary
Enables chemoattractant activity involved in axon guidance and frizzled binding activity. Involved in several processes, including Wnt signaling pathway, planar cell polarity pathway; nervous system development; and stem cell development. Acts upstream of or within several processes, including blood vessel morphogenesis; kidney development; and respiratory system development. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in whole brain E14.5 (RPKM 14.2), CNS E14 (RPKM 11.4) and 16 other tissues See more
Orthologs
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Genomic context

See Wnt7b in Genome Data Viewer
Location:
15 E2; 15 40.39 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85419638..85466022, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85535437..85581821, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 7530416G11 gene Neighboring gene VISTA enhancer mm325 Neighboring gene ribosomal protein L27 pseudogene Neighboring gene expressed sequence AU022754 Neighboring gene STARR-positive B cell enhancer mm9_chr15:85465006-85465307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:85484419-85484572 Neighboring gene long noncoding RNA near Ppara Neighboring gene microRNA let7c-2 Neighboring gene microRNA let7b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity involved in axon guidance PubMed 
enables cytokine activity  
enables frizzled binding  
enables frizzled binding PubMed 
enables protein binding PubMed 
enables receptor ligand activity PubMed 
enables receptor ligand activity  
Items 1 - 25 of 57
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway PubMed 
acts_upstream_of_or_within anatomical structure regression PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis PubMed 
involved_in canonical Wnt signaling pathway  
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
involved_in canonical Wnt signaling pathway  
involved_in cell fate commitment  
acts_upstream_of cell population proliferation PubMed 
involved_in cell proliferation in forebrain PubMed 
acts_upstream_of_or_within central nervous system vasculogenesis PubMed 
involved_in chemoattraction of dopaminergic neuron axon PubMed 
acts_upstream_of_or_within chorio-allantoic fusion PubMed 
acts_upstream_of_or_within developmental growth involved in morphogenesis PubMed 
acts_upstream_of_or_within embryonic organ development PubMed 
acts_upstream_of_or_within embryonic placenta morphogenesis PubMed 
acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium PubMed 
involved_in forebrain regionalization PubMed 
acts_upstream_of_or_within homeostatic process PubMed 
acts_upstream_of_or_within in utero embryonic development PubMed 
acts_upstream_of_or_within inner medullary collecting duct development PubMed 
acts_upstream_of_or_within intracellular oxygen homeostasis PubMed 
acts_upstream_of_or_within lobar bronchus development PubMed 
acts_upstream_of_or_within lung development PubMed 
acts_upstream_of_or_within lung epithelium development PubMed 
acts_upstream_of_or_within lung morphogenesis PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development PubMed 
acts_upstream_of_or_within metabolic process PubMed 
acts_upstream_of_or_within metanephric collecting duct development PubMed 
acts_upstream_of_or_within metanephric epithelium development PubMed 
acts_upstream_of_or_within metanephric loop of Henle development PubMed 
acts_upstream_of_or_within metanephros morphogenesis PubMed 
involved_in negative regulation of neurogenesis PubMed 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway PubMed 
involved_in neuron differentiation  
involved_in neuron projection development  
involved_in neuron projection morphogenesis  
acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
acts_upstream_of osteoblast differentiation PubMed 
acts_upstream_of_or_within outer medullary collecting duct development PubMed 
involved_in positive regulation of JNK cascade  
involved_in positive regulation of JNK cascade  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of gene expression PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation PubMed 
involved_in regulation of cell projection size  
acts_upstream_of_or_within renal inner medulla development PubMed 
acts_upstream_of_or_within renal outer medulla development PubMed 
acts_upstream_of_or_within smooth muscle cell differentiation PubMed 
involved_in stem cell development PubMed 
acts_upstream_of_or_within synapse organization PubMed 
acts_upstream_of_or_within trachea cartilage morphogenesis PubMed 
acts_upstream_of_or_within vasculature development PubMed 
Items 1 - 25 of 57
Component Evidence Code Pubs
located_in cell surface PubMed 
located_in endoplasmic reticulum lumen  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
protein Wnt-7b
Names
wingless-related MMTV integration site 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163633.1NP_001157105.1  protein Wnt-7b isoform 3

    See identical proteins and their annotated locations for NP_001157105.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1, and initiates translation from an in-frame downstream AUG, resulting in a shorter isoform (3) compared to isoform 1.
    Source sequence(s)
    AC162302, AK087499, BC052018, BQ032129
    Consensus CDS
    CCDS49691.1
    UniProtKB/TrEMBL
    E9Q5E3
    Related
    ENSMUSP00000130627.2, ENSMUST00000167968.9
    Conserved Domains (1) summary
    cl38924
    Location:1282
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
  2. NM_001163634.1NP_001157106.1  protein Wnt-7b isoform 2

    See identical proteins and their annotated locations for NP_001157106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1, and encodes a slightly longer isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC052018, BC066003, BQ032129
    Consensus CDS
    CCDS49692.1
    UniProtKB/TrEMBL
    Q6NZR1
    Related
    ENSMUSP00000155014.2, ENSMUST00000229191.2
    Conserved Domains (1) summary
    cd19350
    Location:36353
    wnt_Wnt7b; Wnt domain found in protein Wnt-7b and similar proteins
  3. NM_009528.3NP_033554.3  protein Wnt-7b isoform 1 precursor

    See identical proteins and their annotated locations for NP_033554.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    BC052018, BC058398, BQ032129
    Consensus CDS
    CCDS37171.1
    UniProtKB/Swiss-Prot
    P28047, Q80US5
    Related
    ENSMUSP00000105051.4, ENSMUST00000109424.4
    Conserved Domains (1) summary
    cd19350
    Location:32349
    wnt_Wnt7b; Wnt domain found in protein Wnt-7b and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85419638..85466022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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