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PXMP2 peroxisomal membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 5827, updated on 4-Jan-2025

Summary

Official Symbol
PXMP2provided by HGNC
Official Full Name
peroxisomal membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:9716
See related
Ensembl:ENSG00000176894 MIM:617399; AllianceGenome:HGNC:9716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMP22; MPV17L3
Summary
Located in peroxisomal membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in liver (RPKM 47.9), kidney (RPKM 25.6) and 25 other tissues See more
Orthologs
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Genomic context

See PXMP2 in Genome Data Viewer
Location:
12q24.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132687587..132704985)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132737814..132753863)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133264173..133281571)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 2 Neighboring gene DNA polymerase epsilon, catalytic subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5123 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:133280509-133281382 Neighboring gene uncharacterized LOC124903063 Neighboring gene MPRA-validated peak2052 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5125 Neighboring gene PGAM family member 5, mitochondrial serine/threonine protein phosphatase Neighboring gene RNA, 5S ribosomal pseudogene 379

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Pathways from PubChem

Interactions

General gene information

Potential readthrough

Included gene: PGAM5

Clone Names

  • FLJ54922

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in membrane PubMed 
is_active_in peroxisomal membrane  
located_in peroxisomal membrane PubMed 
located_in peroxisomal membrane  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
peroxisomal membrane protein 2
Names
22 kDa peroxisomal membrane protein
peroxisomal membrane protein 2, 22kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018663.3NP_061133.1  peroxisomal membrane protein 2

    See identical proteins and their annotated locations for NP_061133.1

    Status: VALIDATED

    Source sequence(s)
    AC135586, AF250136, BC073997
    Consensus CDS
    CCDS9279.1
    UniProtKB/Swiss-Prot
    Q9NR77
    Related
    ENSP00000321271.3, ENST00000317479.8
    Conserved Domains (1) summary
    pfam04117
    Location:131193
    Mpv17_PMP22; Mpv17 / PMP22 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132687587..132704985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132737814..132753863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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