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PK1-R Pyrokinin 1 receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41713, updated on 4-Jan-2025

Summary

Official Symbol
PK1-Rprovided by FlyBase
Official Full Name
Pyrokinin 1 receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0038201
Locus tag
Dmel_CG9918
See related
AllianceGenome:FB:FBgn0038201
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.112; anon-WO0170980.113; CG9918; Dmel\CG9918; LstR; Pk1r; Pk1R; PK1r; PK1R; pkr1
Summary
Enables pyrokinin receptor activity. Involved in negative regulation of peptide hormone secretion; neuropeptide signaling pathway; and triglyceride homeostasis. Located in plasma membrane. Used to study obesity. Orthologous to human NMUR1 (neuromedin U receptor 1) and NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See PK1-R in Genome Data Viewer
Location:
88A8-88A8; 3-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14099832..14103122, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9925554..9928844, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46531 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44237 Neighboring gene Odorant receptor 88a

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity PubMed 
enables G protein-coupled receptor activity  
enables G protein-coupled receptor activity PubMed 
enables neuropeptide receptor activity  
enables neuropeptide receptor activity PubMed 
enables pyrokinin receptor activity PubMed 
Component Evidence Code Pubs
located_in membrane  
located_in membrane PubMed 
located_in membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 

General protein information

Preferred Names
pyrokinin 1 receptor
Names
CG9918-PD
CG9918-PE
CPyrokinin 1 receptor
Drm-PK-1 receptor
Lst receptor
PK1-R-PD
PK1-R-PE
pyrokinin 1 R
pyrokinin receptor 1
pyrokinin-1 receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14099832..14103122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260160.1 → NP_001247089.1  pyrokinin 1 receptor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247089.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0IGX8, Q71RH8, Q8ITC9
    Conserved Domains (1) summary
    cd15134
    Location:21 → 358
    7tmA_capaR; neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001014620.2 → NP_001014620.1  pyrokinin 1 receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0IGX8, Q71RH8, Q8ITC9
    Conserved Domains (1) summary
    cd15134
    Location:21 → 358
    7tmA_capaR; neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
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