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CG4372 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37490, updated on 4-Jan-2025

Summary

Official Symbol
CG4372provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034665
Locus tag
Dmel_CG4372
See related
AllianceGenome:FB:FBgn0034665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4372
Summary
Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See CG4372 in Genome Data Viewer
Location:
58A2-58A2; 2-97 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21837605..21838798, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17725110..17726303, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-TCC 2-1 Neighboring gene transfer RNA:Glycine-TCC 2-2

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in lysosome  

General protein information

Preferred Names
uncharacterized protein
Names
CG4372-PA
NP_611615.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21837605..21838798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137771.1NP_611615.1  uncharacterized protein Dmel_CG4372 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611615.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W2C3
    Related
    FBpp0071652, FBtr0071738
    Conserved Domains (1) summary
    cd04513
    Location:54356
    Glycosylasparaginase; Glycosylasparaginase and similar proteins
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