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    Ralb v-ral simian leukemia viral oncogene B [ Mus musculus (house mouse) ]

    Gene ID: 64143, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ralbprovided by MGI
    Official Full Name
    v-ral simian leukemia viral oncogene Bprovided by MGI
    Primary source
    MGI:MGI:1927244
    See related
    Ensembl:ENSMUSG00000004451 AllianceGenome:MGI:1927244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730472O18Rik
    Summary
    Predicted to enable GTPase activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; cellular response to exogenous dsRNA; and positive regulation of metabolic process. Predicted to be located in midbody. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and skin. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALB (RAS like proto-oncogene B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 48.8), large intestine adult (RPKM 23.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ralb in Genome Data Viewer
    Location:
    1 E2.3; 1 52.29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119398035..119432512, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (119470305..119504782, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33490 Neighboring gene predicted gene, 33575 Neighboring gene predicted gene, 46145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:121388591-121388840 Neighboring gene STARR-positive B cell enhancer ABC_E1558 Neighboring gene predicted gene 29454 Neighboring gene RIKEN cDNA 3830432H09 gene Neighboring gene transmembrane protein 185B Neighboring gene predicted gene, 25322

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables ATPase binding  
    enables G protein activity  
    enables GDP binding  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction  
    involved_in apoptotic process  
    involved_in cell division  
    involved_in cellular response to exogenous dsRNA  
    involved_in cellular response to exogenous dsRNA  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in negative regulation of protein binding  
    involved_in positive regulation of autophagosome assembly  
    involved_in positive regulation of autophagosome assembly  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of protein binding  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in receptor internalization  
    involved_in receptor internalization  
    involved_in regulation of exocyst assembly  
    involved_in regulation of exocyst assembly  
    involved_in regulation of exocyst localization  
    involved_in regulation of exocyst localization  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in midbody  
    located_in midbody  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ras-related protein Ral-B
    Names
    v-ral simian leukemia viral oncogene homolog B (ras related)
    NP_071722.1
    XP_006529845.1
    XP_036008626.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022327.5NP_071722.1  ras-related protein Ral-B

      See identical proteins and their annotated locations for NP_071722.1

      Status: VALIDATED

      Source sequence(s)
      AK033193, AK159993, BE943587, BY237628
      Consensus CDS
      CCDS15225.1
      UniProtKB/Swiss-Prot
      Q3TVS5, Q9JIW9
      UniProtKB/TrEMBL
      Q8CCG5
      Related
      ENSMUSP00000004565.9, ENSMUST00000004565.15
      Conserved Domains (1) summary
      cd04139
      Location:15178
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      119398035..119432512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529782.3XP_006529845.1  ras-related protein Ral-B isoform X1

      See identical proteins and their annotated locations for XP_006529845.1

      UniProtKB/Swiss-Prot
      Q3TVS5, Q9JIW9
      UniProtKB/TrEMBL
      Q8CCG5
      Conserved Domains (1) summary
      cd04139
      Location:15178
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
    2. XM_036152733.1XP_036008626.1  ras-related protein Ral-B isoform X1

      UniProtKB/Swiss-Prot
      Q3TVS5, Q9JIW9
      UniProtKB/TrEMBL
      Q8CCG5
      Conserved Domains (1) summary
      cd04139
      Location:15178
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
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