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Prkca protein kinase C, alpha [ Mus musculus (house mouse) ]

Gene ID: 18750, updated on 4-Jan-2025

Summary

Official Symbol
Prkcaprovided by MGI
Official Full Name
protein kinase C, alphaprovided by MGI
Primary source
MGI:MGI:97595
See related
Ensembl:ENSMUSG00000050965 AllianceGenome:MGI:97595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkca
Summary
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity; integrin binding activity; and lipid binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including cone photoreceptor outer segment; intercalated disc; and ooplasm. Part of alphav-beta3 integrin-PKCalpha complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in frontal lobe adult (RPKM 19.9), cortex adult (RPKM 11.1) and 22 other tissues See more
Orthologs
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Genomic context

See Prkca in Genome Data Viewer
Location:
11 E1; 11 70.8 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107824213..108237360, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107933387..108343888, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene predicted gene 11650 Neighboring gene calcium channel, voltage-dependent, gamma subunit 5 Neighboring gene STARR-seq mESC enhancer starr_30997 Neighboring gene STARR-seq mESC enhancer starr_30998 Neighboring gene predicted gene 11657 Neighboring gene microRNA 7223 Neighboring gene predicted gene, 51922 Neighboring gene predicted gene 11655 Neighboring gene STARR-seq mESC enhancer starr_31000 Neighboring gene STARR-seq mESC enhancer starr_31001 Neighboring gene predicted gene, 36709 Neighboring gene apolipoprotein H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables calcium,diacylglycerol-dependent serine/threonine kinase activity PubMed 
enables calcium,diacylglycerol-dependent serine/threonine kinase activity PubMed 
enables calcium,diacylglycerol-dependent serine/threonine kinase activity  
enables diacylglycerol-dependent serine/threonine kinase activity PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity  
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity  
enables enzyme binding  
enables histone H3T6 kinase activity  
enables integrin binding PubMed 
enables lipid binding PubMed 
enables protein binding PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables zinc ion binding  
Items 1 - 25 of 75
Process Evidence Code Pubs
involved_in angiogenesis  
involved_in cell adhesion  
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of_or_within cellular response to carbohydrate stimulus PubMed 
involved_in central nervous system neuron axonogenesis  
acts_upstream_of_or_within chondrocyte differentiation PubMed 
involved_in desmosome assembly  
acts_upstream_of_or_within induction of positive chemotaxis PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway PubMed 
involved_in learning or memory  
acts_upstream_of_or_within muscle cell cellular homeostasis PubMed 
acts_upstream_of_or_within negative regulation of D-glucose import PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
involved_in negative regulation of glial cell apoptotic process  
involved_in negative regulation of glial cell apoptotic process  
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation PubMed 
involved_in negative regulation of translation  
acts_upstream_of_or_within neutrophil chemotaxis PubMed 
acts_upstream_of_or_within peptidyl-serine autophosphorylation PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiotensin-activated signaling pathway  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of bone resorption PubMed 
involved_in positive regulation of cardiac muscle hypertrophy  
involved_in positive regulation of cardiac muscle hypertrophy  
involved_in positive regulation of cell adhesion  
involved_in positive regulation of cell adhesion  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of dense core granule biogenesis PubMed 
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of exocytosis  
acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
involved_in positive regulation of macrophage differentiation PubMed 
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of mitotic cell cycle  
acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of synapse assembly  
involved_in post-translational protein modification  
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in protein phosphorylation PubMed 
acts_upstream_of protein phosphorylation PubMed 
acts_upstream_of protein phosphorylation PubMed 
involved_in protein phosphorylation  
acts_upstream_of_or_within regulation of muscle contraction PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
involved_in regulation of platelet aggregation PubMed 
involved_in regulation of platelet aggregation  
involved_in regulation of receptor-mediated endocytosis  
involved_in regulation of synaptic vesicle exocytosis PubMed 
involved_in regulation of synaptic vesicle exocytosis PubMed 
acts_upstream_of_or_within regulation of the force of heart contraction PubMed 
involved_in response to estradiol  
involved_in response to ethanol  
involved_in response to interleukin-1  
involved_in response to reactive oxygen species  
acts_upstream_of_or_within stem cell differentiation PubMed 
Items 1 - 25 of 75
Items 1 - 20 of 27
Component Evidence Code Pubs
part_of alphav-beta3 integrin-PKCalpha complex PubMed 
located_in apical part of cell PubMed 
located_in axon PubMed 
is_active_in calyx of Held PubMed 
is_active_in calyx of Held PubMed 
is_active_in ciliary basal body  
located_in cone photoreceptor outer segment PubMed 
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in dendrite PubMed 
located_in endoplasmic reticulum  
located_in intercalated disc PubMed 
located_in membrane PubMed 
located_in mitochondrial membrane  
located_in mitochondrion PubMed 
located_in neuronal cell body PubMed 
located_in nucleus PubMed 
located_in ooplasm PubMed 
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in plasma membrane PubMed 
located_in plasma membrane  
is_active_in presynaptic cytosol PubMed 
part_of protein-containing complex PubMed 
part_of protein-containing complex  
Items 1 - 20 of 27

General protein information

Preferred Names
protein kinase C alpha type
Names
PKC-A
PKC-alpha
protein kinase c-alpha
NP_035231.2
XP_036012317.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011101.3NP_035231.2  protein kinase C alpha type

    See identical proteins and their annotated locations for NP_035231.2

    Status: VALIDATED

    Source sequence(s)
    AK147084, AL645535, BF455952
    Consensus CDS
    CCDS25573.1
    UniProtKB/Swiss-Prot
    P20444
    UniProtKB/TrEMBL
    Q4VA93
    Related
    ENSMUSP00000062392.5, ENSMUST00000059595.11
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    107824213..108237360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156424.1XP_036012317.1  protein kinase C alpha type isoform X1

    UniProtKB/Swiss-Prot
    P20444
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05615
    Location:328684
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    cd20833
    Location:3592
    C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    cd20836
    Location:102155
    C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
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