U.S. flag

An official website of the United States government

TBC1D23 TBC1 domain family member 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33289, updated on 4-Jan-2025

Summary

Official Symbol
TBC1D23provided by FlyBase
Official Full Name
TBC1 domain family member 23provided by FlyBase
Primary source
FLYBASE:FBgn0031304
Locus tag
Dmel_CG4552
See related
AllianceGenome:FB:FBgn0031304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4552; Dmel\CG4552; tbc1
Summary
Predicted to enable GTPase activator activity. Involved in positive regulation of intracellular transport. Located in recycling endosome and trans-Golgi network. Is expressed in several structures, including embryonic/larval midgut primordium; foregut primordium; gland; gut section; and hindgut proper primordium. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 11. Orthologous to human TBC1D23 (TBC1 domain family member 23). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TBC1D23 in Genome Data Viewer
Location:
21F1-21F1; 2-2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1129316..1132411)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1129316..1132411)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pinocchio Neighboring gene iris Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity  
Component Evidence Code Pubs
located_in recycling endosome PubMed 
is_active_in trans-Golgi network  
located_in trans-Golgi network PubMed 

General protein information

Preferred Names
TBC1 domain family member 23
Names
CG4552-PA
TBC1D23-PA

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1129316..1132411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134725.2NP_608569.1  TBC1 domain family member 23 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608569.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRS6, Q9VPW9
    Related
    FBpp0077621
    Conserved Domains (2) summary
    smart00450
    Location:330429
    RHOD; Rhodanese Homology Domain
    pfam00566
    Location:34233
    RabGAP-TBC; Rab-GTPase-TBC domain
External link. Please review our privacy policy.