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Fstl1 follistatin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 14314, updated on 4-Jan-2025

Summary

Official Symbol
Fstl1provided by MGI
Official Full Name
follistatin-like 1provided by MGI
Primary source
MGI:MGI:102793
See related
Ensembl:ENSMUSG00000022816 AllianceGenome:MGI:102793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fstl; TSC-36
Summary
Predicted to enable calcium ion binding activity and heparin binding activity. Involved in endothelial cell differentiation; endothelial cell migration; and negative regulation of apoptotic process. Acts upstream of or within hematopoietic stem cell homeostasis. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; limb; and sensory organ. Used to study pulmonary emphysema. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in limb E14.5 (RPKM 177.9), bladder adult (RPKM 102.9) and 12 other tissues See more
Orthologs
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Genomic context

See Fstl1 in Genome Data Viewer
Location:
16 B3; 16 26.48 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37597417..37656878)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37777055..37836516)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9 pseudogene Neighboring gene predicted gene, 46547 Neighboring gene STARR-seq mESC enhancer starr_40793 Neighboring gene STARR-seq mESC enhancer starr_40795 Neighboring gene STARR-seq mESC enhancer starr_40798 Neighboring gene predicted gene, 41452 Neighboring gene butyrophilin-like 12 Neighboring gene leucine rich repeat containing 58 Neighboring gene actin, beta, cytoplasmic (Actb) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding  
enables heparin binding  
enables protein binding PubMed 
Component Evidence Code Pubs
is_active_in extracellular region  
located_in extracellular space PubMed 

General protein information

Preferred Names
follistatin-related protein 1
Names
TGF-beta-inducible protein TSC-36
follistatin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008047.5NP_032073.2  follistatin-related protein 1 precursor

    See identical proteins and their annotated locations for NP_032073.2

    Status: PROVISIONAL

    Source sequence(s)
    AC129539
    Consensus CDS
    CCDS37339.1
    UniProtKB/Swiss-Prot
    Q62356, Q6GTX2, Q99JI9
    Related
    ENSMUSP00000110411.3, ENSMUST00000114763.3
    Conserved Domains (5) summary
    smart00274
    Location:2951
    FOLN; Follistatin-N-terminal domain-like
    smart00280
    Location:5296
    KAZAL; Kazal type serine protease inhibitors
    pfam13499
    Location:147218
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:147218
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl17735
    Location:231278
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    37597417..37656878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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