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Hacl 2-hydroxyacyl-CoA lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37285, updated on 4-Jan-2025

Summary

Official Symbol
Haclprovided by FlyBase
Official Full Name
2-hydroxyacyl-CoA lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034488
Locus tag
Dmel_CG11208
See related
AllianceGenome:FB:FBgn0034488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.196; CG11208; Dmel\CG11208; HACL1
Summary
Predicted to enable 2-hydroxyacyl-CoA lyase activity and thiamine pyrophosphate binding activity. Predicted to be involved in fatty acid alpha-oxidation. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut primordium; gut section; and head epidermis primordium. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Hacl in Genome Data Viewer
Location:
56F11-56F11; 2-90 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20242752..20245388, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16130257..16132893, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene EF-hand domain containing 1.2 Neighboring gene pickpocket 6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2-hydroxyacyl-CoA lyase activity  
enables catalytic activity  
enables magnesium ion binding  
enables thiamine pyrophosphate binding  
enables thiamine pyrophosphate binding  
Process Evidence Code Pubs
involved_in fatty acid alpha-oxidation  
involved_in fatty acid alpha-oxidation PubMed 
Component Evidence Code Pubs
is_active_in peroxisome  
located_in peroxisome PubMed 
located_in peroxisome PubMed 

General protein information

Preferred Names
2-hydroxyacyl-CoA lyase
Names
2-hydroxyacyl-CoA lyase 1
CG11208-PA
Hacl-PA
NP_611460.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20242752..20245388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137616.3 → NP_611460.1  2-hydroxyacyl-CoA lyase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611460.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3B7
    Related
    FBpp0085630
    Conserved Domains (4) summary
    cd07035
    Location:8 → 161
    TPP_PYR_POX_like; Pyrimidine (PYR) binding domain of POX and related proteins
    PRK09259
    Location:8 → 552
    PRK09259; putative oxalyl-CoA decarboxylase; Validated
    cd02004
    Location:367 → 550
    TPP_BZL_OCoD_HPCL; Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL ...
    pfam00205
    Location:195 → 322
    TPP_enzyme_M; Thiamine pyrophosphate enzyme, central domain
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