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IREG3 iron-regulated protein 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832740, updated on 18-Sep-2024

Summary

Official Symbol
IREG3
Official Full Name
iron-regulated protein 3
Primary source
TAIR:AT5G26820
Locus tag
AT5G26820
See related
Araport:AT5G26820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATIREG3; F2P16.6; F2P16_6; IRON REGULATED 3; iron-regulated protein 3; MAR1; MULTIPLE ANTIBIOTIC RESISTANCE 1; RTS3
Summary
Mutations in MAR1 confer resistance, while MAR1 overexpression causes hypersensitivity to multiple aminoglycoside antibiotics. Localizes to the chloroplast envelope. MAR1 may act as a plastid transporter involved in cellular iron homeostasis.
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Genomic context

See IREG3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (9433569..9437158)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene B3 domain protein Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Threonyl-tRNA synthetase Neighboring gene uncharacterized protein

General gene information

NM_122564.5

Gene Ontology Provided by TAIR

Component Evidence Code Pubs
located_in chloroplast PubMed 
located_in chloroplast envelope PubMed 
located_in mitochondrion PubMed 
located_in plasma membrane  

General protein information

Preferred Names
iron-regulated protein 3
NP_198034.2
  • iron-regulated protein 3 (IREG3); CONTAINS InterPro DOMAIN/s: Ferroporti-1 (InterPro:IPR009716), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: iron regulated 2 (TAIR:AT5G03570.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    9433569..9437158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122564.5NP_198034.2  iron-regulated protein 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198034.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04629, Q8W4E7
    UniProtKB/TrEMBL
    A0A178UFP2, A0A654G577
    Conserved Domains (1) summary
    pfam06963
    Location:146569
    FPN1; Ferroportin1 (FPN1)
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