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MLH1 MUTL-homologue 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 826493, updated on 18-Sep-2024

Summary

Official Symbol
MLH1
Official Full Name
MUTL-homologue 1
Primary source
TAIR:AT4G09140
Locus tag
AT4G09140
See related
Araport:AT4G09140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA MUTL-HOMOLOGUE 1; ATMLH1; F23J3.170; F23J3_170; MUTL-homologue 1
Summary
Encodes a protein with similarity to Mut1 DNA mismatch repair protein, from E.coli. The protein is expressed during prophase I of meiosis, colocalizes with MLH3 throughout pachytene and is dependent on MLH3 for proper localization.
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Genomic context

See MLH1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Sequence:
Chromosome: 4; NC_003075.7 (5816942..5821066, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene miscRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

Genomic Sequence:
NC_003075.7

Pathways from PubChem

General gene information

NM_001340612.1
NM_116983.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP-dependent DNA damage sensor activity  
enables mismatched DNA binding  
enables protein-macromolecule adaptor activity PubMed 
Component Evidence Code Pubs
located_in chromatin PubMed 
part_of mismatch repair complex  
located_in nucleus  

General protein information

Preferred Names
MUTL-homologue 1
NP_567345.2
  • MUTL-homologue 1 (MLH1); FUNCTIONS IN: protein binding, bridging; INVOLVED IN: in 6 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Mlh1 (InterPro:IPR011186), DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA mismatch repair protein, C-terminal (InterPro:IPR013507), DNA mismatch repair protein, N-terminal (InterPro:IPR014763), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA mismatch repair protein (InterPro:IPR002099), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: DNA mismatch repair protein, putative (TAIR:AT4G02460.1); Has 6802 Blast hits to 6727 proteins in 2342 species: Archae - 68; Bacteria - 4480; Metazoa - 469; Fungi - 496; Plants - 114; Viruses - 0; Other Eukaryotes - 1175 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    5816942..5821066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116983.3NP_567345.2  MUTL-homologue 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567345.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9C5F9, Q9ZRV4
    UniProtKB/TrEMBL
    A0A654FML5
    Conserved Domains (4) summary
    cd03483
    Location:232358
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    TIGR00585
    Location:28338
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:453737
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl00075
    Location:49159
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
  2. NM_001340612.1NP_001328542.1  MUTL-homologue 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B4Y5
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