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    Pde12 phosphodiesterase 12 [ Mus musculus (house mouse) ]

    Gene ID: 211948, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Pde12provided by MGI
    Official Full Name
    phosphodiesterase 12provided by MGI
    Primary source
    MGI:MGI:2443226
    See related
    Ensembl:ENSMUSG00000043702 AllianceGenome:MGI:2443226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2-PDE; 2'-PDE; E430028B21Rik
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including cellular response to interferon-alpha; innate immune response; and mRNA catabolic process. Located in mitochondrion. Is expressed in brain; foregut; genitourinary system; and skin. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 10.0), ovary adult (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde12 in Genome Data Viewer
    Location:
    14 A3; 14 16.09 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26381113..26390823, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26664117..26669846, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 6A Neighboring gene STARR-seq mESC enhancer starr_36241 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene ARF GTPase 4 Neighboring gene microRNA 7672 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415 Neighboring gene STARR-seq mESC enhancer starr_36242 Neighboring gene STARR-seq mESC enhancer starr_36244 Neighboring gene ankyrin repeat and SOCS box-containing 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis. Wei Q, et al. Eur J Pharmacol, 2024 Mar 15. PMID 38325798
    2. Overview of PDEs and their regulation. Omori K, et al. Circ Res, 2007 Feb 16. PMID 17307970
    3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.
      Title: PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity  
    enables exonuclease activity  
    enables metal ion binding  
    enables poly(A)-specific ribonuclease activity  
    enables poly(A)-specific ribonuclease activity  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response  
    involved_in antiviral innate immune response  
    involved_in cellular response to dsRNA  
    involved_in cellular response to dsRNA  
    involved_in cellular response to interferon-alpha  
    involved_in cellular response to interferon-alpha  
    involved_in cellular response to type II interferon  
    involved_in cellular response to type II interferon  
    involved_in mRNA processing  
    involved_in mitochondrial mRNA catabolic process  
    involved_in mitochondrial mRNA catabolic process  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in nucleic acid metabolic process  
    involved_in positive regulation of viral genome replication  
    involved_in positive regulation of viral genome replication  
    involved_in regulation of mitochondrial mRNA stability  
    involved_in regulation of mitochondrial mRNA stability  
    Component Evidence Code Pubs
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  

    General protein information

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    Preferred Names
    2',5'-phosphodiesterase 12
    Names
    2'-phosphodiesterase
    mitochondrial deadenylase
    NP_848783.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178668.4 → NP_848783.3  2',5'-phosphodiesterase 12

      See identical proteins and their annotated locations for NP_848783.3

      Status: VALIDATED

      Source sequence(s)
      AC121919
      Consensus CDS
      CCDS26882.1
      UniProtKB/Swiss-Prot
      Q3TIU4, Q3TTY4, Q6P2L5, Q8BKH8, Q8BTS8, Q8BUQ5
      Related
      ENSMUSP00000059666.10, ENSMUST00000052932.10
      Conserved Domains (1) summary
      cl00490
      Location:298 → 607
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      26381113..26390823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TIU4.2 GenPept UniProtKB/Swiss-Prot:Q3TIU4

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