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Cxadr coxsackie virus and adenovirus receptor [ Mus musculus (house mouse) ]

Gene ID: 13052, updated on 4-Jan-2025

Summary

Official Symbol
Cxadrprovided by MGI
Official Full Name
coxsackie virus and adenovirus receptorprovided by MGI
Primary source
MGI:MGI:1201679
See related
Ensembl:ENSMUSG00000022865 AllianceGenome:MGI:1201679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAR; MCAR; MCVADR; 2610206D03Rik
Summary
This gene encodes a protein that is part of the Cortical Thymocyte marker in Xenopus (CTX) subfamily within the immunoglobulin superfamily. Members of this subfamily, predominantly expressed on the surface of endothelial and epithelial cells, help establish cell polarity and provide a barrier function, regulating migration of immune cells. This protein, first identified as the receptor for adenovirus subgroup C and coxsakieviruses group B, is developmentally regulated and plays an important role in cardiac development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression
Broad expression in CNS E18 (RPKM 24.6), whole brain E14.5 (RPKM 17.4) and 23 other tissues See more
Orthologs
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Genomic context

See Cxadr in Genome Data Viewer
Location:
16 C3.1; 16 45.28 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78098114..78156673)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78301226..78359785)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E330011O21 gene Neighboring gene predicted gene, 25916 Neighboring gene BTG anti-proliferation factor 3 Neighboring gene predicted gene, 25038

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding  
enables PDZ domain binding  
enables beta-catenin binding PubMed 
enables beta-catenin binding  
enables cell adhesion molecule binding  
enables cell adhesion molecule binding  
enables cell adhesion molecule binding  
enables cell adhesive protein binding involved in AV node cell-bundle of His cell communication PubMed 
enables connexin binding PubMed 
enables identical protein binding  
enables integrin binding  
enables protein binding PubMed 
enables signaling receptor binding  
Items 1 - 25 of 28
Process Evidence Code Pubs
involved_in AV node cell to bundle of His cell communication PubMed 
involved_in AV node cell-bundle of His cell adhesion involved in cell communication PubMed 
involved_in actin cytoskeleton organization  
involved_in actin cytoskeleton organization  
acts_upstream_of_or_within cardiac muscle cell development PubMed 
acts_upstream_of cardiac muscle cell proliferation PubMed 
involved_in cell-cell adhesion PubMed 
acts_upstream_of_or_within cell-cell junction organization PubMed 
involved_in defense response to virus  
involved_in epithelial structure maintenance  
involved_in epithelial structure maintenance  
involved_in gamma-delta T cell activation PubMed 
involved_in germ cell migration PubMed 
acts_upstream_of_or_within heart development PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in homotypic cell-cell adhesion  
involved_in homotypic cell-cell adhesion  
involved_in homotypic cell-cell adhesion  
acts_upstream_of_or_within mitochondrion organization PubMed 
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation PubMed 
involved_in neutrophil chemotaxis  
involved_in neutrophil chemotaxis  
involved_in positive regulation of epithelial cell proliferation involved in wound healing PubMed 
involved_in regulation of AV node cell action potential PubMed 
involved_in regulation of synaptic vesicle endocytosis PubMed 
involved_in regulation of synaptic vesicle endocytosis PubMed 
involved_in transepithelial transport  
Items 1 - 25 of 28
Items 1 - 20 of 42
Component Evidence Code Pubs
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse PubMed 
located_in acrosomal vesicle PubMed 
located_in adherens junction  
located_in adherens junction  
located_in apicolateral plasma membrane  
located_in apicolateral plasma membrane  
is_active_in basolateral plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
is_active_in bicellular tight junction  
located_in bicellular tight junction PubMed 
located_in bicellular tight junction  
located_in cell body PubMed 
located_in cell junction  
located_in cell-cell junction PubMed 
located_in cell-cell junction  
located_in cytoplasm  
located_in cytoplasm  
located_in extracellular region  
located_in extracellular space  
located_in filopodium PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in growth cone PubMed 
is_active_in intercalated disc  
located_in intercalated disc PubMed 
located_in intercalated disc  
located_in membrane raft  
located_in membrane raft  
located_in neuromuscular junction  
located_in neuron projection PubMed 
located_in neuron projection  
located_in nucleoplasm  
located_in nucleus  
located_in plasma membrane  
located_in plasma membrane  
is_active_in presynaptic membrane PubMed 
is_active_in presynaptic membrane PubMed 
part_of protein-containing complex  
Items 1 - 20 of 42

General protein information

Preferred Names
coxsackievirus and adenovirus receptor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025192.3NP_001020363.1  coxsackievirus and adenovirus receptor homolog isoform a precursor

    See identical proteins and their annotated locations for NP_001020363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC130844, AK141274, AK145569
    Consensus CDS
    CCDS28276.1
    UniProtKB/Swiss-Prot
    O09052, P97792, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8
    UniProtKB/TrEMBL
    Q3TV22
    Related
    ENSMUSP00000023572.8, ENSMUST00000023572.15
    Conserved Domains (3) summary
    cd12087
    Location:238271
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00047
    Location:154222
    ig; Immunoglobulin domain
    pfam07686
    Location:24138
    V-set; Immunoglobulin V-set domain
  2. NM_001276263.1NP_001263192.1  coxsackievirus and adenovirus receptor homolog isoform c precursor

    See identical proteins and their annotated locations for NP_001263192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (c) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC130844
    Consensus CDS
    CCDS88952.1
    UniProtKB/TrEMBL
    A0A338P6N1
    Related
    ENSMUSP00000156281.2, ENSMUST00000231356.2
    Conserved Domains (2) summary
    smart00410
    Location:27137
    IG_like; Immunoglobulin like
    pfam07686
    Location:24138
    V-set; Immunoglobulin V-set domain
  3. NM_009988.4NP_034118.1  coxsackievirus and adenovirus receptor homolog isoform b precursor

    See identical proteins and their annotated locations for NP_034118.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate terminal 3' exon and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC130844, Y11929
    Consensus CDS
    CCDS37379.1
    UniProtKB/TrEMBL
    Q3TV22
    Related
    ENSMUSP00000109867.3, ENSMUST00000114229.4
    Conserved Domains (3) summary
    cd12087
    Location:238271
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00047
    Location:154222
    ig; Immunoglobulin domain
    pfam07686
    Location:24138
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    78098114..78156673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248956.1XP_030104816.1  coxsackievirus and adenovirus receptor homolog isoform X1

    UniProtKB/Swiss-Prot
    O09052, P97792, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8
    UniProtKB/TrEMBL
    Q3TV22
    Conserved Domains (3) summary
    cd12087
    Location:238271
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00047
    Location:154222
    ig; Immunoglobulin domain
    pfam07686
    Location:24138
    V-set; Immunoglobulin V-set domain
  2. XM_006522884.5XP_006522947.1  coxsackievirus and adenovirus receptor homolog isoform X2

    See identical proteins and their annotated locations for XP_006522947.1

    UniProtKB/TrEMBL
    Q3TV22
    Conserved Domains (3) summary
    cd12087
    Location:238271
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00047
    Location:154222
    ig; Immunoglobulin domain
    pfam07686
    Location:24138
    V-set; Immunoglobulin V-set domain
  3. XM_006522883.5XP_006522946.1  coxsackievirus and adenovirus receptor homolog isoform X1

    See identical proteins and their annotated locations for XP_006522946.1

    UniProtKB/Swiss-Prot
    O09052, P97792, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8
    UniProtKB/TrEMBL
    Q3TV22
    Conserved Domains (3) summary
    cd12087
    Location:238271
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00047
    Location:154222
    ig; Immunoglobulin domain
    pfam07686
    Location:24138
    V-set; Immunoglobulin V-set domain
  4. XM_017316864.2XP_017172353.1  coxsackievirus and adenovirus receptor homolog isoform X3

    Conserved Domains (2) summary
    cd12087
    Location:109142
    TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
    pfam00047
    Location:2593
    ig; Immunoglobulin domain
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