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HDR 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829585, updated on 18-Sep-2024

Summary

Official Symbol
HDR
Official Full Name
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Primary source
TAIR:AT4G34350
Locus tag
AT4G34350
See related
Araport:AT4G34350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
4-hydroxy-3-methylbut-2-enyl diphosphate reductase; CHLOROPLAST BIOGENESIS 6; CLB6; F10M10.120; F10M10_120; ISPH
Summary
Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.
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Genomic context

See HDR in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (16428407..16431144, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein, putative (DUF677) Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 8 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene RING/U-box superfamily protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

NM_119600.4

Gene Ontology Provided by TAIR

General protein information

Preferred Names
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
NP_567965.1
  • 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; INVOLVED IN: response to antibiotic, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: LytB protein (InterPro:IPR003451); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    16428407..16431144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119600.4NP_567965.1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_567965.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHZ9, Q56WI5, Q5EGH0, Q94B35, Q9SZ00
    UniProtKB/TrEMBL
    A0A178V3K9, A0A5S9XZ93, A0A654FVY2
    Conserved Domains (1) summary
    PLN02821
    Location:1465
    PLN02821; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
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