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Pkn1 protein kinase N1 [ Mus musculus (house mouse) ]

Gene ID: 320795, updated on 4-Jan-2025

Summary

Official Symbol
Pkn1provided by MGI
Official Full Name
protein kinase N1provided by MGI
Primary source
MGI:MGI:108022
See related
Ensembl:ENSMUSG00000057672 AllianceGenome:MGI:108022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBK; Pkn; PAK1; PRK1; Stk3; Prkcl1; F730027O18Rik
Summary
Enables protein kinase activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; regulation of germinal center formation; and spleen development. Located in cytoplasmic vesicle. Is expressed in several structures, including brown fat; genitourinary system; gut; nervous system; and vascular system. Orthologous to human PKN1 (protein kinase N1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 55.4), spleen adult (RPKM 49.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pkn1 in Genome Data Viewer
Location:
8 C2; 8 40.22 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84393162..84425819, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83666533..83699181, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene STARR-seq mESC enhancer starr_22093 Neighboring gene STARR-positive B cell enhancer ABC_E1372 Neighboring gene STARR-positive B cell enhancer ABC_E11744 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene STARR-positive B cell enhancer ABC_E9319 Neighboring gene STARR-seq mESC enhancer starr_22095 Neighboring gene STARR-positive B cell enhancer ABC_E562 Neighboring gene DEAD box helicase 39a Neighboring gene microRNA 1668 Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86260655-86260859 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86263836-86264037 Neighboring gene predicted gene, 46046

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 27
Function Evidence Code Pubs
enables ATP binding  
enables calcium,diacylglycerol-dependent serine/threonine kinase activity  
enables chromatin binding  
enables chromatin binding  
enables diacylglycerol-dependent serine/threonine kinase activity  
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T11 kinase activity  
enables histone binding  
enables histone binding  
enables histone deacetylase binding  
enables histone deacetylase binding  
enables nuclear androgen receptor binding  
enables nuclear androgen receptor binding  
enables nuclear receptor coactivator activity  
enables nuclear receptor coactivator activity  
enables protein binding PubMed 
enables protein kinase C binding  
enables protein kinase C binding  
enables protein kinase activity PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables small GTPase binding  
enables small GTPase binding  
Items 1 - 25 of 27
Process Evidence Code Pubs
acts_upstream_of_or_within B cell apoptotic process PubMed 
acts_upstream_of_or_within B cell homeostasis PubMed 
involved_in chromatin remodeling  
involved_in epithelial cell migration  
involved_in epithelial cell migration  
acts_upstream_of_or_within hyperosmotic response PubMed 
involved_in intracellular signal transduction  
acts_upstream_of_or_within negative regulation of B cell proliferation PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in post-translational protein modification  
involved_in post-translational protein modification  
involved_in protein phosphorylation  
involved_in regulation of cell motility  
involved_in regulation of cell motility  
acts_upstream_of_or_within regulation of germinal center formation PubMed 
acts_upstream_of_or_within regulation of immunoglobulin production PubMed 
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within renal system process PubMed 
involved_in signal transduction  
acts_upstream_of_or_within spleen development PubMed 
Component Evidence Code Pubs
located_in cleavage furrow  
located_in cleavage furrow  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasmic vesicle PubMed 
located_in endosome  
located_in endosome  
located_in midbody  
located_in midbody  
located_in nucleus  
located_in nucleus  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase N1
Names
protein kinase C-like 1
protein kinase C-like PKN
protein-kinase C-related kinase 1
serine-threonine protein kinase N
serine/threonine kinase 3
NP_001186522.1
NP_796236.2
XP_030099481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199593.1NP_001186522.1  serine/threonine-protein kinase N1 isoform 1

    See identical proteins and their annotated locations for NP_001186522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC164432, AK089431, AK149649, CX568360
    Consensus CDS
    CCDS57627.1
    UniProtKB/Swiss-Prot
    P70268
    Related
    ENSMUSP00000116235.2, ENSMUST00000144258.8
    Conserved Domains (5) summary
    cd08687
    Location:397484
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:37103
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:126197
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd05589
    Location:624948
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:214286
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  2. NM_177262.4NP_796236.2  serine/threonine-protein kinase N1 isoform 2

    See identical proteins and their annotated locations for NP_796236.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC164432, BC052923, CX568360
    Consensus CDS
    CCDS22459.1
    UniProtKB/Swiss-Prot
    P70268, Q3UEA6, Q7TST2, Q8BTL8
    Related
    ENSMUSP00000005616.9, ENSMUST00000005616.16
    Conserved Domains (6) summary
    PTZ00263
    Location:616939
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd08687
    Location:392479
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:3298
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:121192
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd05589
    Location:619943
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:209281
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84393162..84425819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243621.2XP_030099481.1  serine/threonine-protein kinase N1 isoform X1

    Conserved Domains (5) summary
    cd08687
    Location:397484
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:37103
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:126197
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd05589
    Location:624948
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:214286
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RNA

  1. XR_004934844.1 RNA Sequence

  2. XR_004934845.1 RNA Sequence

  3. XR_004934843.1 RNA Sequence

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