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TIAM2 TIAM Rac1 associated GEF 2 [ Homo sapiens (human) ]

Gene ID: 26230, updated on 4-Jan-2025

Summary

Official Symbol
TIAM2provided by HGNC
Official Full Name
TIAM Rac1 associated GEF 2provided by HGNC
Primary source
HGNC:HGNC:11806
See related
Ensembl:ENSG00000146426 MIM:604709; AllianceGenome:HGNC:11806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STEF; TIAM-2
Summary
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 5.7), brain (RPKM 4.1) and 18 other tissues See more
Orthologs
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Genomic context

See TIAM2 in Genome Data Viewer
Location:
6q25.2-q25.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (154995315..155257723)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (156197278..156459744)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (155316449..155578857)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SR-related CTD associated factor 8 Neighboring gene RNA, U6 small nuclear 824, pseudogene Neighboring gene MPRA-validated peak6235 silencer Neighboring gene Sharpr-MPRA regulatory region 2718 Neighboring gene microRNA 1273c Neighboring gene ReSE screen-validated silencer GRCh37_chr6:155259719-155259894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:155272494-155272994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155287362-155288008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155316951-155317556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155316343-155316950 Neighboring gene lysophosphatidylcholine acyltransferase 3 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155340532-155341032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155434365-155434864 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:155440095-155440876 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:155440877-155441659 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:155448114-155449313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155450845-155451460 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17702 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:155499148-155499350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25304 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr6:155506493-155507300 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr6:155507301-155508106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155508589-155509092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155517063-155517562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155539515-155540016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155540017-155540516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:155541579-155542078 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:155544888-155546087 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155568469-155569164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155574917-155575491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155575492-155576065 Neighboring gene transcription factor B1, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155635711-155636701 Neighboring gene claudin 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:155748671-155749628 Neighboring gene NADPH oxidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of T-cell lymphoma invasion and metastasis 2 (TIAM2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Potential readthrough

Included gene: SCAF8

Clone Names

  • FLJ41865

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol  
located_in extracellular exosome PubMed 
located_in filopodium  
located_in growth cone  
located_in lamellipodium  
is_active_in membrane  
located_in perikaryon  
is_active_in synapse  

General protein information

Preferred Names
rho guanine nucleotide exchange factor TIAM2
Names
SIF and TIAM1-like exchange factor
T cell lymphoma invasion and metastasis 2
T-lymphoma invasion and metastasis-inducing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010927.3NP_001010927.2  rho guanine nucleotide exchange factor TIAM2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34559.1
    UniProtKB/TrEMBL
    B7Z624
    Related
    ENSP00000275246.7, ENST00000275246.11
    Conserved Domains (2) summary
    smart00325
    Location:28217
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:219391
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
  2. NM_001384546.1NP_001371475.1  rho guanine nucleotide exchange factor TIAM2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL136228, AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34558.1
    UniProtKB/Swiss-Prot
    B2RP56, C9JZV2, Q6NXN9, Q6ZUP9, Q8IVF5, Q9UFG6, Q9UKV9, Q9UKW0
    UniProtKB/TrEMBL
    Q59EY7
    Related
    ENSP00000437188.2, ENST00000461783.7
    Conserved Domains (6) summary
    smart00325
    Location:11031292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:888973
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12941466
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:645742
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:811881
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. NM_001384547.1NP_001371476.1  rho guanine nucleotide exchange factor TIAM2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34558.1
    UniProtKB/Swiss-Prot
    B2RP56, C9JZV2, Q6NXN9, Q6ZUP9, Q8IVF5, Q9UFG6, Q9UKV9, Q9UKW0
    UniProtKB/TrEMBL
    Q59EY7
    Related
    ENSP00000353528.4, ENST00000360366.8
    Conserved Domains (6) summary
    smart00325
    Location:11031292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:888973
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12941466
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:645742
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:811881
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. NM_012454.4NP_036586.3  rho guanine nucleotide exchange factor TIAM2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL136228, AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34558.1
    UniProtKB/Swiss-Prot
    B2RP56, C9JZV2, Q6NXN9, Q6ZUP9, Q8IVF5, Q9UFG6, Q9UKV9, Q9UKW0
    UniProtKB/TrEMBL
    Q59EY7
    Related
    ENSP00000507157.1, ENST00000682666.1
    Conserved Domains (6) summary
    smart00325
    Location:11031292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:888973
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12941466
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:645742
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:811881
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    154995315..155257723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    156197278..156459744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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