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Kdelr1 KDEL endoplasmic reticulum protein retention receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361577, updated on 4-Jan-2025

Summary

Official Symbol
Kdelr1provided by RGD
Official Full Name
KDEL endoplasmic reticulum protein retention receptor 1provided by RGD
Primary source
RGD:1306764
See related
EnsemblRapid:ENSRNOG00000021082 AllianceGenome:RGD:1306764
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within T cell apoptotic process and T cell differentiation. Located in cis-Golgi network and endoplasmic reticulum. Orthologous to human KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 401.1), Heart (RPKM 335.3) and 9 other tissues See more
Orthologs
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Genomic context

See Kdelr1 in Genome Data Viewer
Location:
1q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105483598..105494587)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96347258..96358145)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101859346..101870232)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483106 Neighboring gene glutamate-rich WD repeat containing 1 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2D Neighboring gene U4 spliceosomal RNA Neighboring gene synaptogyrin 4 Neighboring gene transmembrane protein 143

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Clone Names

  • MGC109169

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ER retention sequence binding  
enables KDEL sequence binding  
enables KDEL sequence binding  
Component Evidence Code Pubs
located_in COPI-coated vesicle membrane  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in Golgi membrane  
is_active_in cis-Golgi network  
located_in cis-Golgi network PubMed 
located_in cis-Golgi network  
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum-Golgi intermediate compartment  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane  

General protein information

Preferred Names
ER lumen protein-retaining receptor 1
Names
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KDEL receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017385.1 → NP_001017385.1  ER lumen protein-retaining receptor 1

    See identical proteins and their annotated locations for NP_001017385.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092600
    UniProtKB/Swiss-Prot
    Q569A6
    UniProtKB/TrEMBL
    A6JB97
    Related
    ENSRNOP00000028627.3, ENSRNOT00000028627.6
    Conserved Domains (1) summary
    pfam00810
    Location:28 → 169
    ER_lumen_recept; ER lumen protein retaining receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105483598..105494587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266819.1 → XP_063122889.1  ER lumen protein-retaining receptor 1 isoform X1

    UniProtKB/TrEMBL
    A6JB97
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