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Ube2i ubiquitin-conjugating enzyme E2I [ Mus musculus (house mouse) ]

Gene ID: 22196, updated on 4-Jan-2025

Summary

Official Symbol
Ube2iprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Iprovided by MGI
Primary source
MGI:MGI:107365
See related
Ensembl:ENSMUSG00000015120 AllianceGenome:MGI:107365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBC9; Ubce9; Ubce2i; 5830467E05Rik
Summary
Enables HLH domain binding activity and SUMO conjugating enzyme activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nuclear export; and protein sumoylation. Acts upstream of or within positive regulation of canonical NF-kappaB signal transduction. Located in nuclear body. Part of SUMO ligase complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including early embryo; forebrain; forelimb bud; limb; and oocyte. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 68.8), whole brain E14.5 (RPKM 68.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ube2i in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25479484..25494965, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25260510..25275799, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34 Neighboring gene predicted gene, 25921

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables HLH domain binding PubMed 
enables RING-like zinc finger domain binding  
enables SUMO conjugating enzyme activity  
enables SUMO conjugating enzyme activity PubMed 
enables SUMO conjugating enzyme activity  
enables SUMO transferase activity  
enables bHLH transcription factor binding  
enables enzyme binding  
enables ionotropic glutamate receptor binding  
enables protein binding PubMed 
enables small protein activating enzyme binding  
enables transcription coregulator binding  
enables transcription factor binding  
enables ubiquitin-protein transferase activity  
Process Evidence Code Pubs
involved_in cell division  
involved_in chromosome segregation  
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in nuclear export PubMed 
involved_in nuclear export  
involved_in positive regulation of SUMO transferase activity  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of cell migration  
involved_in protein modification process PubMed 
involved_in protein sumoylation  
involved_in protein sumoylation PubMed 
involved_in protein sumoylation  
involved_in protein sumoylation  
involved_in protein sumoylation  
Items 1 - 20 of 21
Component Evidence Code Pubs
located_in PML body  
part_of SUMO ligase complex PubMed 
part_of SUMO ligase complex  
is_active_in Schaffer collateral - CA1 synapse PubMed 
is_active_in Schaffer collateral - CA1 synapse PubMed 
located_in cytoplasm  
located_in cytosol  
located_in dendrite  
located_in fibrillar center  
is_active_in glutamatergic synapse PubMed 
located_in nuclear body PubMed 
located_in nuclear body  
located_in nuclear envelope  
part_of nuclear pore PubMed 
is_active_in nucleoplasm PubMed 
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
is_active_in postsynaptic cytosol PubMed 
is_active_in presynaptic cytosol PubMed 
part_of transferase complex  
Items 1 - 20 of 21

General protein information

Preferred Names
SUMO-conjugating enzyme UBC9
Names
RING-type E3 SUMO transferase UBC9
SUMO-protein ligase
ubiquitin carrier protein 9
ubiquitin carrier protein I
ubiquitin-protein ligase I
NP_001171080.1
NP_001171081.1
NP_001344623.1
NP_035795.1
XP_006524112.1
XP_036016378.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177609.1NP_001171080.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_001171080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK150575, AK166657, AK166930
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    UniProtKB/TrEMBL
    A0AAA9WWE2
    Related
    ENSMUSP00000134261.2, ENSMUST00000173084.9
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  2. NM_001177610.1NP_001171081.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_001171081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC122454, AK166930
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    UniProtKB/TrEMBL
    A0AAA9WWE2
    Related
    ENSMUSP00000134350.2, ENSMUST00000174031.9
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  3. NM_001357694.1NP_001344623.1  SUMO-conjugating enzyme UBC9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC122454, CD776278
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    UniProtKB/TrEMBL
    A0AAA9WWE2
    Related
    ENSMUSP00000134161.3, ENSMUST00000173621.9
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  4. NM_011665.4NP_035795.1  SUMO-conjugating enzyme UBC9

    See identical proteins and their annotated locations for NP_035795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK005058, BY074880
    Consensus CDS
    CCDS28513.1
    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    UniProtKB/TrEMBL
    A0AAA9WWE2
    Related
    ENSMUSP00000134491.2, ENSMUST00000173713.9
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25479484..25494965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524049.5XP_006524112.1  SUMO-conjugating enzyme UBC9 isoform X1

    See identical proteins and their annotated locations for XP_006524112.1

    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    UniProtKB/TrEMBL
    A0AAA9WWE2
    Related
    ENSMUSP00000055714.10, ENSMUST00000049911.17
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
  2. XM_036160485.1XP_036016378.1  SUMO-conjugating enzyme UBC9 isoform X1

    UniProtKB/Swiss-Prot
    P63280, Q6RUT3
    UniProtKB/TrEMBL
    A0AAA9WWE2
    Related
    ENSMUSP00000159860.1, ENSMUST00000249684.1
    Conserved Domains (1) summary
    pfam00179
    Location:8152
    UQ_con; Ubiquitin-conjugating enzyme
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