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Wdr13 WD repeat domain 13 [ Mus musculus (house mouse) ]

Gene ID: 73447, updated on 4-Jan-2025

Summary

Official Symbol
Wdr13provided by MGI
Official Full Name
WD repeat domain 13provided by MGI
Primary source
MGI:MGI:1914661
See related
Ensembl:ENSMUSG00000031166 AllianceGenome:MGI:1914661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mMg21; DXHXS7467e; 1700060B08Rik; 5730411P10Rik
Summary
Enables promoter-specific chromatin binding activity. Acts upstream of or within negative regulation of type B pancreatic cell proliferation. Predicted to be located in centriolar satellite; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Orthologous to human WDR13 (WD repeat domain 13). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 49.2), frontal lobe adult (RPKM 36.1) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr13 in Genome Data Viewer
Location:
X A1.1; X 3.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7989540..7999134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8123301..8132858, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Wiskott-Aldrich syndrome Neighboring gene STARR-seq mESC enhancer starr_46687 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E7686 Neighboring gene RNA binding motif (RNP1, RRM) protein 3 Neighboring gene RNA binding motif protein 3, opposite strand Neighboring gene TBC1 domain family, member 25 Neighboring gene STARR-seq mESC enhancer starr_46689

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

General gene information

Clone Names

  • MGC117822, MGC158990

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in centriolar satellite  
located_in centriolar satellite  
located_in nucleoplasm  
located_in nucleoplasm  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
WD repeat-containing protein 13
Names
memory-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290783.1NP_001277712.1  WD repeat-containing protein 13 isoform 2

    See identical proteins and their annotated locations for NP_001277712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AL663032, BC057366, BC080853
    Consensus CDS
    CCDS72338.1
    UniProtKB/TrEMBL
    Q8K412, Q9CYL7, S4R225
    Conserved Domains (2) summary
    COG2319
    Location:73393
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:129165
    7WD40; WD40 repeat [structural motif]
  2. NM_026137.5NP_080413.2  WD repeat-containing protein 13 isoform 1

    See identical proteins and their annotated locations for NP_080413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK017549, AL663032, BC057366, BC080853
    Consensus CDS
    CCDS29986.1
    UniProtKB/Swiss-Prot
    Q91V09
    UniProtKB/TrEMBL
    Q32P16, Q8K412, Q9CYL7
    Related
    ENSMUSP00000033506.7, ENSMUST00000033506.13
    Conserved Domains (2) summary
    COG2319
    Location:165485
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:221257
    7WD40; WD40 repeat [structural motif]
  3. NM_028542.1NP_082818.1  WD repeat-containing protein 13 isoform 2

    See identical proteins and their annotated locations for NP_082818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AK006837, AL663032, BC057366, BC080853, CF739215
    Consensus CDS
    CCDS72338.1
    UniProtKB/TrEMBL
    Q8K412, Q9CYL7, S4R225
    Related
    ENSMUSP00000138468.2, ENSMUST00000130832.8
    Conserved Domains (2) summary
    COG2319
    Location:73393
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:129165
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7989540..7999134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527703.4XP_006527766.1  WD repeat-containing protein 13 isoform X1

    See identical proteins and their annotated locations for XP_006527766.1

    UniProtKB/Swiss-Prot
    Q91V09
    UniProtKB/TrEMBL
    Q32P16, Q8K412, Q9CYL7
    Related
    ENSMUSP00000111286.2, ENSMUST00000115623.8
    Conserved Domains (2) summary
    COG2319
    Location:165485
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:221257
    7WD40; WD40 repeat [structural motif]
  2. XM_036162112.1XP_036018005.1  WD repeat-containing protein 13 isoform X3

    Conserved Domains (2) summary
    COG2319
    Location:43363
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:99135
    7WD40; WD40 repeat [structural motif]
  3. XM_036162110.1XP_036018003.1  WD repeat-containing protein 13 isoform X1

    UniProtKB/Swiss-Prot
    Q91V09
    UniProtKB/TrEMBL
    Q32P16, Q8K412, Q9CYL7
    Conserved Domains (2) summary
    COG2319
    Location:165485
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:221257
    7WD40; WD40 repeat [structural motif]
  4. XM_036162111.1XP_036018004.1  WD repeat-containing protein 13 isoform X2

    UniProtKB/TrEMBL
    Q8K412, Q9CYL7, S4R225
    Conserved Domains (2) summary
    COG2319
    Location:73393
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:129165
    7WD40; WD40 repeat [structural motif]
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