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Mettl23 methyltransferase like 23 [ Mus musculus (house mouse) ]

Gene ID: 74319, updated on 4-Jan-2025

Summary

Official Symbol
Mettl23provided by MGI
Official Full Name
methyltransferase like 23provided by MGI
Primary source
MGI:MGI:1921569
See related
Ensembl:ENSMUSG00000090266 AllianceGenome:MGI:1921569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110005A03Rik; 1500035B17Rik; 4933424L15Rik
Summary
Enables histone H3R17 methyltransferase activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of with a positive effect on epigenetic programing of male pronucleus. Located in cytoplasm and female pronucleus. Is active in male pronucleus. Is expressed in embryo. Used to study glaucoma. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 16.8), mammary gland adult (RPKM 12.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mettl23 in Genome Data Viewer
Location:
11 E2; 11 81.49 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116734341..116740566)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116843515..116849740)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116644149-116644366 Neighboring gene matrix-remodelling associated 7 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene jumonji domain containing 6 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene STARR-seq mESC enhancer starr_31229 Neighboring gene mannoside acetylglucosaminyltransferase 5, isoenzyme B Neighboring gene predicted gene, 33829

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in female pronucleus PubMed 
is_active_in male pronucleus PubMed 
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
part_of protein-containing complex  
part_of protein-containing complex  

General protein information

Preferred Names
histone-arginine methyltransferase METTL23
Names
methyltransferase-like protein 23
probable methyltransferase-like protein 23
NP_083141.3
XP_006534423.1
XP_036012939.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028865.3NP_083141.3  histone-arginine methyltransferase METTL23

    See identical proteins and their annotated locations for NP_083141.3

    Status: VALIDATED

    Source sequence(s)
    AK003450, AW490033, BY122329
    Consensus CDS
    CCDS25679.2
    UniProtKB/Swiss-Prot
    A2AA28, Q8R2Z2, Q9D1J5
    Related
    ENSMUSP00000101978.4, ENSMUST00000106370.10
    Conserved Domains (1) summary
    cl17173
    Location:63189
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116734341..116740566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534360.4XP_006534423.1  histone-arginine methyltransferase METTL23 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:3126
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_036157046.1XP_036012939.1  histone-arginine methyltransferase METTL23 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:3126
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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