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ina-1 Integrin alpha ina-1 [ Caenorhabditis elegans ]

Gene ID: 176296, updated on 4-Jan-2025

Summary

Official Symbol
ina-1
Official Full Name
Integrin alpha ina-1
Primary source
WormBase:WBGene00002081
Locus tag
CELE_F54G8.3
See related
AllianceGenome:WB:WBGene00002081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables transmembrane signaling receptor activity. Involved in several processes, including cell-cell adhesion mediated by integrin; generation of neurons; and nematode male tail tip morphogenesis. Located in phagocytic cup. Part of integrin complex. Is expressed in several structures, including ABplaapppp; hermaphrodite gonad; neurons; ventral nerve cord; and vulE. Used to study cancer and epilepsy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; junctional epidermolysis bullosa; junctional epidermolysis bullosa with pyloric atresia; and muscular disease. Orthologous to several human genes including ITGA6 (integrin subunit alpha 6). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See ina-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
9
Sequence:
Chromosome: III; NC_003281.10 (9168073..9172802, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Patched-related protein 9 Neighboring gene ncRNA Neighboring gene putative diacylglycerol kinase 3 Neighboring gene pseudo Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables integrin binding  
enables laminin binding PubMed 
enables protein binding PubMed 
enables transmembrane signaling receptor activity PubMed 
Process Evidence Code Pubs
involved_in animal organ development  
involved_in animal organ morphogenesis PubMed 
involved_in axonal fasciculation PubMed 
involved_in body morphogenesis PubMed 
involved_in cell adhesion  
involved_in cell adhesion mediated by integrin  
involved_in cell-cell adhesion  
involved_in cell-cell adhesion mediated by integrin PubMed 
involved_in cell-matrix adhesion  
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
involved_in mesodermal cell migration PubMed 
involved_in nematode larval development PubMed 
involved_in nematode male tail tip morphogenesis PubMed 
involved_in nervous system development  
involved_in neuron migration PubMed 
involved_in positive regulation of distal tip cell migration PubMed 
involved_in regulation of synaptic transmission, GABAergic PubMed 
Component Evidence Code Pubs
located_in cell projection  
located_in cytoplasmic vesicle  
is_active_in external side of plasma membrane  
part_of integrin complex  
part_of integrin complex  
part_of integrin complex PubMed 
located_in membrane PubMed 
located_in membrane  
located_in phagocytic cup PubMed 
located_in phagocytic cup  
located_in phagocytic vesicle membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
Integrin alpha ina-1
NP_499032.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9168073..9172802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066631.8NP_499032.1  Integrin alpha ina-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03600
    Conserved Domains (2) summary
    smart00191
    Location:317362
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:4951005
    Integrin_alpha2; Integrin alpha
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