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    Sirt2 sirtuin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361532, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sirt2provided by RGD
    Official Full Name
    sirtuin 2provided by RGD
    Primary source
    RGD:621481
    See related
    EnsemblRapid:ENSRNOG00000020102 AllianceGenome:RGD:621481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables NAD-dependent protein lysine deacetylase activity and tubulin deacetylase activity. Involved in several processes, including regulation of nervous system development; regulation of postsynaptic neurotransmitter receptor internalization; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and metabolic dysfunction-associated steatotic liver disease. Biomarker of cocaine dependence and intermittent claudication. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 274.8), Muscle (RPKM 207.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sirt2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93181472..93204499)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84053883..84076975)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86948866..86971954)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC134483092 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene Ras and Rab interactor-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105900

    Gene Ontology Provided by RGD

    Items 1 - 25 of 47
    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables NAD+ binding  
    enables NAD+ binding  
    enables NAD+ binding  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD+-protein poly-ADP-ribosyltransferase activity  
    enables NAD-dependent protein demyristoylase activity  
    enables NAD-dependent protein demyristoylase activity  
    enables NAD-dependent protein demyristoylase activity  
    enables NAD-dependent protein depalmitoylase activity  
    enables NAD-dependent protein depalmitoylase activity  
    enables NAD-dependent protein depalmitoylase activity  
    enables NAD-dependent protein lysine deacetylase activity PubMed 
    enables NAD-dependent protein lysine deacetylase activity  
    enables NAD-dependent protein lysine deacetylase activity  
    enables chromatin binding  
    enables chromatin binding  
    enables chromatin binding  
    enables histone H3K14 deacetylase activity, NAD-dependent  
    enables histone H3K18 deacetylase activity, NAD-dependent  
    enables histone H3K4 deacetylase activity, NAD-dependent  
    enables histone H3K56 deacetylase activity, NAD-dependent  
    enables histone H3K9 deacetylase activity, NAD-dependent  
    enables histone H4K16 deacetylase activity, NAD-dependent  
    enables histone H4K16 deacetylase activity, NAD-dependent  
    enables histone H4K16 deacetylase activity, NAD-dependent  
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables histone deacetylase activity  
    enables histone deacetylase activity  
    enables histone deacetylase activity, NAD-dependent  
    enables histone deacetylase activity, NAD-dependent  
    NOT enables histone deacetylase activity, NAD-dependent  
    enables histone deacetylase activity, NAD-dependent  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables protein lysine deacetylase activity  
    enables protein lysine deacetylase activity  
    enables tubulin deacetylase activity PubMed 
    enables tubulin deacetylase activity  
    NOT enables tubulin deacetylase activity  
    enables tubulin deacetylase activity  
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 47
    Items 1 - 25 of 100
    Process Evidence Code Pubs
    involved_in NLRP3 inflammasome complex assembly  
    acts_upstream_of NLRP3 inflammasome complex assembly  
    involved_in autophagy  
    involved_in cell division  
    involved_in cellular response to caloric restriction  
    involved_in cellular response to caloric restriction  
    involved_in cellular response to caloric restriction  
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to epinephrine stimulus  
    involved_in cellular response to hypoxia  
    involved_in cellular response to hypoxia  
    involved_in cellular response to hypoxia  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxidative stress  
    acts_upstream_of_or_within chromatin organization  
    involved_in epigenetic regulation of gene expression  
    involved_in epigenetic regulation of gene expression  
    involved_in epigenetic regulation of gene expression  
    involved_in lipid catabolic process  
    involved_in meiotic cell cycle  
    involved_in myelination in peripheral nervous system  
    involved_in myelination in peripheral nervous system PubMed 
    involved_in myelination in peripheral nervous system  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of NLRP3 inflammasome complex assembly  
    acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of oligodendrocyte differentiation PubMed 
    involved_in negative regulation of oligodendrocyte progenitor proliferation PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of protein catabolic process  
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in negative regulation of striated muscle tissue development  
    involved_in negative regulation of striated muscle tissue development  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in peptidyl-lysine deacetylation  
    involved_in peptidyl-lysine deacetylation  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore  
    involved_in positive regulation of attachment of spindle microtubules to kinetochore  
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell division  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of fatty acid biosynthetic process  
    involved_in positive regulation of meiotic nuclear division  
    involved_in positive regulation of meiotic nuclear division  
    involved_in positive regulation of meiotic nuclear division  
    involved_in positive regulation of oocyte maturation  
    involved_in positive regulation of oocyte maturation  
    involved_in positive regulation of oocyte maturation  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in post-translational protein modification  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein deacetylation PubMed 
    NOT involved_in protein deacetylation  
    involved_in protein deacetylation  
    involved_in protein deacetylation  
    involved_in rDNA heterochromatin formation  
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    acts_upstream_of_or_within regulation of fat cell differentiation  
    involved_in regulation of myelination  
    involved_in regulation of myelination PubMed 
    involved_in regulation of myelination  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in response to cocaine PubMed 
    involved_in substantia nigra development PubMed 
    involved_in tubulin deacetylation PubMed 
    NOT involved_in tubulin deacetylation  
    acts_upstream_of_or_within tubulin deacetylation  
    involved_in tubulin deacetylation  
    Items 1 - 25 of 100
    Items 1 - 20 of 66
    Component Evidence Code Pubs
    located_in Schmidt-Lanterman incisure PubMed 
    located_in Schmidt-Lanterman incisure  
    located_in Schmidt-Lanterman incisure  
    located_in Schmidt-Lanterman incisure  
    located_in centriole  
    located_in centriole  
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in chromosome  
    located_in chromosome  
    located_in chromosome  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in glial cell projection PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in growth cone  
    located_in heterochromatin PubMed 
    located_in juxtaparanode region of axon PubMed 
    located_in lateral loop PubMed 
    located_in meiotic spindle  
    located_in meiotic spindle  
    located_in meiotic spindle  
    located_in microtubule  
    located_in microtubule  
    located_in midbody  
    located_in midbody  
    located_in midbody  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in myelin sheath PubMed 
    located_in myelin sheath  
    located_in myelin sheath  
    located_in myelin sheath  
    located_in myelin sheath abaxonal region PubMed 
    located_in nucleolus  
    located_in nucleolus  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in paranodal junction PubMed 
    located_in paranodal junction  
    located_in paranodal junction  
    located_in paranodal junction  
    located_in paranode region of axon PubMed 
    located_in perikaryon PubMed 
    located_in perikaryon  
    located_in perikaryon  
    located_in perikaryon  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in spindle  
    located_in spindle  
    located_in terminal loop PubMed 
    Items 1 - 20 of 66

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-2
    Names
    5E5 antigen
    NAD-dependent deacetylase sirtuin-2
    NAD-dependent protein defatty-acylase sirtuin-2
    SIR2-like protein 2
    regulatory protein SIR2 homolog 2
    NP_001386559.1
    NP_001386560.1
    XP_063122487.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399630.1NP_001386559.1  NAD-dependent protein deacetylase sirtuin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JWM2, A0A8L2UN46, A6J9K9
      Related
      ENSRNOP00000080491.2, ENSRNOT00000095928.2
    2. NM_001399631.1NP_001386560.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5RJQ4
      Related
      ENSRNOP00000059450.3, ENSRNOT00000064153.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93181472..93204499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266417.1XP_063122487.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJQ4
      Related
      ENSRNOP00000107408.1, ENSRNOT00000151497.1

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