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caup caupolican [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39440, updated on 27-Dec-2024

Summary

Official Symbol
caupprovided by FlyBase
Official Full Name
caupolicanprovided by FlyBase
Primary source
FLYBASE:FBgn0015919
Locus tag
Dmel_CG10605
See related
AllianceGenome:FB:FBgn0015919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Caup; CG10605; Dmel\CG10605; iro; Iro; iro-C; Iro-C; IRO-C; IroC
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including compound eye morphogenesis; imaginal disc-derived wing vein specification; and muscle cell fate commitment. Predicted to be active in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; imaginal disc; presumptive wing vein; segment; and transverse muscle cell. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See caup in Genome Data Viewer
Location:
69D1-69D1; 3-38 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12609631..12621798)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12602731..12614898)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43612 Neighboring gene sosondowah Neighboring gene araucan Neighboring gene long non-coding RNA:CR32111 Neighboring gene long non-coding RNA:CR43431

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in nucleus  
located_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
caupolican
Names
CG10605-PA
caup-PA
cauplican
iroquis complex
iroquois
iroquois gene complex
iroquois-complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12609631..12621798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079322.3 → NP_524046.2  caupolican [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524046.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54269, Q5BIH8, Q5U1A6, Q8MR03, Q9VU00
    Related
    FBpp0075641
    Conserved Domains (2) summary
    smart00548
    Location:455 → 472
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    pfam05920
    Location:244 → 283
    Homeobox_KN; Homeobox KN domain
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