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Oxsr1 oxidative-stress responsive 1 [ Mus musculus (house mouse) ]

Gene ID: 108737, updated on 31-Dec-2024

Summary

Official Symbol
Oxsr1provided by MGI
Official Full Name
oxidative-stress responsive 1provided by MGI
Primary source
MGI:MGI:1917378
See related
Ensembl:ENSMUSG00000036737 AllianceGenome:MGI:1917378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osr1; mKIAA1101; 2210022N24Rik; 2810422B09Rik
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to be active in cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.9), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs
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Genomic context

See Oxsr1 in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119067498..119154475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119238432..119322684, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 13 Neighboring gene STARR-seq mESC enhancer starr_25469 Neighboring gene solute carrier family 22 (organic cation transporter), member 13b Neighboring gene STARR-positive B cell enhancer ABC_E1119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119231914-119232305 Neighboring gene STARR-positive B cell enhancer ABC_E11425 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene acetyl-Coenzyme A acyltransferase 1A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 34
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables identical protein binding  
enables identical protein binding  
enables magnesium ion binding  
enables magnesium ion binding  
enables protein binding PubMed 
enables protein kinase binding  
enables protein kinase binding  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 34
Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in cell volume homeostasis  
involved_in cell volume homeostasis  
involved_in cellular hyperosmotic response  
involved_in cellular hyperosmotic response  
involved_in cellular hyperosmotic response  
involved_in cellular hypotonic response PubMed 
involved_in cellular response to chemokine PubMed 
involved_in cellular response to chemokine  
involved_in chemokine (C-C motif) ligand 21 signaling pathway PubMed 
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway  
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway  
involved_in chromatin remodeling  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction PubMed 
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in negative regulation of potassium ion transmembrane transport PubMed 
involved_in negative regulation of potassium ion transmembrane transporter activity PubMed 
involved_in osmosensory signaling pathway  
involved_in osmosensory signaling pathway  
involved_in peptidyl-threonine phosphorylation PubMed 
involved_in peptidyl-threonine phosphorylation  
involved_in positive regulation of T cell chemotaxis  
involved_in positive regulation of T cell chemotaxis PubMed 
involved_in positive regulation of T cell chemotaxis  
involved_in protein autophosphorylation  
involved_in protein autophosphorylation  
involved_in protein phosphorylation  
involved_in protein phosphorylation  
involved_in renal sodium ion absorption  
involved_in renal sodium ion absorption  
involved_in response to oxidative stress PubMed 
involved_in response to xenobiotic stimulus PubMed 
involved_in signal transduction  
Items 1 - 25 of 34
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in cytosol  

General protein information

Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress-responsive 1 protein
NP_001346511.1
NP_598746.2
XP_030099862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359582.1NP_001346511.1  serine/threonine-protein kinase OSR1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC128702
    Consensus CDS
    CCDS57714.1
    UniProtKB/Swiss-Prot
    Q6P9R2, Q8BVZ9, Q8C0B9
    UniProtKB/TrEMBL
    Q6ZPX7
    Conserved Domains (1) summary
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase
  2. NM_133985.2NP_598746.2  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_598746.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC128702, BC060645
    Consensus CDS
    CCDS57714.1
    UniProtKB/Swiss-Prot
    Q6P9R2, Q8BVZ9, Q8C0B9
    UniProtKB/TrEMBL
    Q6ZPX7
    Related
    ENSMUSP00000042155.5, ENSMUST00000040853.11
    Conserved Domains (1) summary
    cd06610
    Location:15291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RNA

  1. NR_045693.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC128702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119067498..119154475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244002.2XP_030099862.1  serine/threonine-protein kinase OSR1 isoform X1

    Conserved Domains (2) summary
    pfam12202
    Location:242299
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    cl21453
    Location:199
    PKc_like; Protein Kinases, catalytic domain
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