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Tada2a transcriptional adaptor 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 360581, updated on 9-Dec-2024

Summary

Official Symbol
Tada2aprovided by RGD
Official Full Name
transcriptional adaptor 2Aprovided by RGD
Primary source
RGD:1309959
See related
EnsemblRapid:ENSRNOG00000002757 AllianceGenome:RGD:1309959
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tada2l
Summary
Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including regulation of cell division; regulation of embryonic development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Predicted to be located in mitotic spindle. Predicted to be part of ATAC complex and SAGA complex. Predicted to be active in nucleus. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 105.5), Brain (RPKM 87.3) and 9 other tissues See more
Orthologs
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Genomic context

See Tada2a in Genome Data Viewer
Location:
10q26
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (69463966..69511612, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68966502..69014149, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (71393701..71441435, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene synergin, gamma Neighboring gene uncharacterized LOC134480839 Neighboring gene ribosomal protein S15a, pseudogene 2 Neighboring gene dual specificity phosphatase 14 Neighboring gene similar to human chromosome 17 open reading frame 78 Neighboring gene acetyl-CoA carboxylase alpha Neighboring gene ribosomal protein L17, pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding  
enables chromatin binding  
contributes_to histone acetyltransferase activity  
enables transcription coactivator activity  
enables transcription coactivator activity  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in biological_process  
involved_in chromatin organization  
acts_upstream_of_or_within chromatin organization  
involved_in chromatin remodeling  
involved_in mitotic cell cycle  
acts_upstream_of_or_within mitotic cell cycle  
involved_in positive regulation of DNA-templated transcription  
involved_in regulation of DNA-templated transcription  
involved_in regulation of cell cycle  
involved_in regulation of cell cycle  
involved_in regulation of cell division  
involved_in regulation of cell division  
involved_in regulation of embryonic development  
involved_in regulation of embryonic development  
acts_upstream_of_or_within regulation of protein phosphorylation  
involved_in regulation of protein stability  
acts_upstream_of_or_within regulation of protein stability  
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of tubulin deacetylation  
acts_upstream_of_or_within regulation of tubulin deacetylation  
involved_in regulation of tubulin deacetylation  
Component Evidence Code Pubs
part_of ATAC complex  
part_of ATAC complex  
part_of SAGA complex  
part_of SAGA-type complex  
located_in mitotic spindle  
located_in mitotic spindle  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
transcriptional adapter 2-alpha
Names
ADA2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012141.1NP_001012141.1  transcriptional adapter 2-alpha

    See identical proteins and their annotated locations for NP_001012141.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079084
    UniProtKB/Swiss-Prot
    A1EC76, Q6AYE3
    UniProtKB/TrEMBL
    A0A8I6ABC7
    Related
    ENSRNOP00000003699.6, ENSRNOT00000003699.7
    Conserved Domains (1) summary
    COG5114
    Location:28440
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    69463966..69511612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247041.4XP_006247103.1  transcriptional adapter 2-alpha isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0R7, A0A8I6ABC7
    Related
    ENSRNOP00000071555.2, ENSRNOT00000087769.3
    Conserved Domains (4) summary
    COG5114
    Location:28420
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:5498
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam04433
    Location:354420
    SWIRM; SWIRM domain
    cl00295
    Location:1544
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
  2. XM_063269382.1XP_063125452.1  transcriptional adapter 2-alpha isoform X7

  3. XM_039086364.2XP_038942292.1  transcriptional adapter 2-alpha isoform X6

    Conserved Domains (1) summary
    COG5114
    Location:28320
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  4. XM_039086363.1XP_038942291.1  transcriptional adapter 2-alpha isoform X4

    UniProtKB/TrEMBL
    A0A8L2UHP0
    Conserved Domains (1) summary
    COG5114
    Location:4396
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  5. XM_006247042.4XP_006247104.1  transcriptional adapter 2-alpha isoform X3

    UniProtKB/TrEMBL
    A0A8L2UHP0
    Related
    ENSRNOP00000089252.1, ENSRNOT00000119062.2
    Conserved Domains (4) summary
    COG5114
    Location:4416
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:5094
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02335
    Location:340
    ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam04433
    Location:350416
    SWIRM; SWIRM domain
  6. XM_039086362.2XP_038942290.1  transcriptional adapter 2-alpha isoform X1

    UniProtKB/Swiss-Prot
    A1EC76, Q6AYE3
    UniProtKB/TrEMBL
    A0A8I6ABC7
    Conserved Domains (1) summary
    COG5114
    Location:28440
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  7. XM_039086365.2XP_038942293.1  transcriptional adapter 2-alpha isoform X8

    Conserved Domains (1) summary
    COG5114
    Location:1276
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
  8. XM_063269381.1XP_063125451.1  transcriptional adapter 2-alpha isoform X5

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